Metabolic syndrome update

Abstract The metabolic syndrome is a multiplex risk factor for atherosclerotic cardiovascular disease and type 2 diabetes. It is composed of atherogenic dyslipidemia, elevated blood pressure, insulin resistance and elevated glucose, a pro-thrombotic state, and a pro-inflammatory state. Excess energy...

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Bibliographic Details
Published in:	Trends in cardiovascular medicine 2016-05, Vol.26 (4), p.364-373
Main Author:	Grundy, Scott M., MD, PhD
Format:	Article
Language:	eng
Subjects:	Atherosclerosis - diagnosis Atherosclerosis - epidemiology Atherosclerosis - therapy Bariatric Surgery Cardiovascular Cardiovascular Agents - therapeutic use Diabetes Dyslipidemia Dyslipidemias - diagnosis Dyslipidemias - epidemiology Dyslipidemias - therapy Humans Hyperglycemia Hyperglycemia - diagnosis Hyperglycemia - epidemiology Hyperglycemia - therapy Hypertension Hypertension - diagnosis Hypertension - epidemiology Hypertension - therapy Hypoglycemic Agents - therapeutic use Hypolipidemic Agents - therapeutic use Insulin resistance Metabolic syndrome Metabolic Syndrome - diagnosis Metabolic Syndrome - epidemiology Metabolic Syndrome - therapy Nutrition Obesity Obesity - diagnosis Obesity - epidemiology Obesity - therapy Risk Factors Risk Reduction Behavior Treatment Outcome Tumor necrosis factor-TNF
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Summary:	Abstract The metabolic syndrome is a multiplex risk factor for atherosclerotic cardiovascular disease and type 2 diabetes. It is composed of atherogenic dyslipidemia, elevated blood pressure, insulin resistance and elevated glucose, a pro-thrombotic state, and a pro-inflammatory state. Excess energy intake and concomitant obesity are the major drivers of the syndrome. Lifestyle intervention can reverse metabolic risk factors, but at times, drug therapies or bariatric surgery may be required to control more overt risk factors.
ISSN:	1050-1738 1873-2615