68Ga Prostate-Specific Membrane Antigen Uptake in Renal Cell Cancer Lymph Node Metastases

ABSTRACTGa prostate-specific membrane antigen (PSMA)-HBED-CC PET/CT in a patient with a history of both prostate cancer (PC) and renal cell cancer (RCC) shows high PSMA expression in the residual right seminal vesicle suggestive of local recurrence of PC as well as suspected PSMA-positive mediastina...

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Bibliographic Details
Published in:Clinical nuclear medicine 2016-05, Vol.41 (5), p.e261-e262
Main Authors: Einspieler, Ingo, Tauber, Robert, Maurer, Tobias, Schwaiger, Markus, Eiber, Matthias
Format: Article
Language:English
Subjects:
Acetates
Aged
Antigens, Surface - metabolism
Carcinoma, Renal Cell - diagnostic imaging
Carcinoma, Renal Cell - pathology
Ethylenediamines
Gallium Radioisotopes
Glutamate Carboxypeptidase II - metabolism
Humans
Lymphatic Metastasis
Male
Neoplasm Recurrence, Local - diagnostic imaging
Positron Emission Tomography Computed Tomography
Prostatic Neoplasms - diagnostic imaging
Radiopharmaceuticals
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Summary:ABSTRACTGa prostate-specific membrane antigen (PSMA)-HBED-CC PET/CT in a patient with a history of both prostate cancer (PC) and renal cell cancer (RCC) shows high PSMA expression in the residual right seminal vesicle suggestive of local recurrence of PC as well as suspected PSMA-positive mediastinal, retroperitoneal, and iliac lymph nodes. Regarding the latter, biopsy revealed lymph node metastases from RCC excluding PC metastases. This case exemplarily demonstrates that high PSMA expression in RCC metastases can potentially mimic PC metastases. Thus, for accurate interpretation of imaging results in PC patients with additional primary tumors, knowledge of PSMA expression of non-PC tissue is necessary.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000001128