Factors Associated With 20-Year Cumulative Risk of Infection After Aseptic Index Revision Total Knee Arthroplasty

Abstract Background The purpose of this study was to calculate the cumulative risk of periprosthetic joint infection (PJI) after aseptic index knee revisions and to identify the surgical, perioperative, and medical comorbidity risk factors associated with deep infection. Methods We retrospectively r...

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Bibliographic Details
Published in:	The Journal of arthroplasty 2016-04, Vol.31 (4), p.872-877
Main Authors:	Nikolaus, O. Brant, MD, McLendon, Paul B., MD, Hanssen, Arlen D., MD, Mabry, Tad M., MD, Berbari, Elie F., MD, Sierra, Rafael J., MD
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Arthroplasty, Replacement, Knee - adverse effects aseptic revision Female Humans infection Knee Joint - surgery Male Middle Aged Orthopedics Prosthesis Failure Prosthesis-Related Infections - epidemiology Prosthesis-Related Infections - etiology Reoperation Retrospective Studies revision TKA Risk Factors risk factors of infection Time Factors TKA Young Adult
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Summary:	Abstract Background The purpose of this study was to calculate the cumulative risk of periprosthetic joint infection (PJI) after aseptic index knee revisions and to identify the surgical, perioperative, and medical comorbidity risk factors associated with deep infection. Methods We retrospectively reviewed 1802 aseptic index revision total knee arthroplasties performed at our institution from 1970 to 2000. From this cohort, there were 60 reoperations performed for deep infection. Results The cumulative risk of infection at 1, 5, 10, and 20 years after index revision was 1%, 2.4%, 3.3%, and 5.6%, respectively. Conclusions Male gender, use of constrained implants, increased operative times, increased Charlson Comorbidity Index, and a history of liver disease were all significantly associated with PJI. The development of cardiovascular disease, endocrine disorders, and renal disease were also associated with PJI.
ISSN:	0883-5403 1532-8406