Radical hysterectomy with or without para-aortic lymphadenectomy for patients with stage IB2, IIA2, and IIB cervical cancer: outcomes for a series of 308 patients

Background Although many studies have already shown that lymph node metastasis is one of the major prognostic factors for cervical cancer, the therapeutic significance of para-aortic lymphadenectomy for the surgical treatment of cervical cancer remains controversial. Methods A total of 308 patients...

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Bibliographic Details
Published in:International journal of clinical oncology 2016-04, Vol.21 (2), p.359-366
Main Authors: Tsuruga, Tetsushi, Fujimoto, Asaha, Kawana, Kei, Mori, Mayuyo, Hasumi, Yoko, Kino, Nao, Tomio, Kensuke, Miura, Shiho, Tanikawa, Michihiro, Sone, Kenbun, Miyamoto, Yuichiro, Ikeda, Yuji, Kojima, Satoko, Adachi, Katsuyuki, Nagasaka, Kazunori, Matsumoto, Yoko, Arimoto, Takahide, Oda, Katsutoshi, Nakagawa, Shunsuke, Horie, Koji, Yasugi, Toshiharu, Yokota, Harushige, Osuga, Yutaka, Fujii, Tomoyuki
Format: Article
Language:English
Subjects:
Adult
Aged
Cancer Research
Cervical cancer
Female
Humans
Hysterectomy - mortality
Kaplan-Meier Estimate
Lymph Node Excision - mortality
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic Metastasis
Lymphatic system
Medicine
Medicine & Public Health
Metastasis
Middle Aged
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Neoplasm Staging
Oncology
Original Article
Prognosis
Proportional Hazards Models
Retrospective Studies
Studies
Surgical Oncology
Survival Rate
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - surgery
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Summary:Background Although many studies have already shown that lymph node metastasis is one of the major prognostic factors for cervical cancer, the therapeutic significance of para-aortic lymphadenectomy for the surgical treatment of cervical cancer remains controversial. Methods A total of 308 patients diagnosed with stage IB2, IIA2, or IIB cervical cancer and treated with radical hysterectomy were retrospectively investigated to assess the incidence of para-aortic lymph node metastasis and the clinicopathological factors linked to cervical cancer prognosis. Results Para-aortic lymph node metastases were pathologically confirmed in 13 of the 136 patients (9.6 %) who underwent para-aortic lymphadenectomy. The incidence of para-aortic lymph node metastasis was significantly higher in the patients who had common iliac lymph node metastases (odds ratio 31.5, p  
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-015-0907-3