Drugs of abuse, cytostatic drugs and iodinated contrast media in tap water from the Madrid region (central Spain):A case study to analyse their occurrence and human health risk characterization

This work analyses the presence of forty-eight emerging pollutants, including twenty-five drugs of abuse and metabolites, seventeen cytostatic drugs and six iodinated contrast media, in tap water from the Madrid Region. Analysis of the target compounds in the tap water was performed by means of (on-...

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Bibliographic Details
Published in:Environment international 2016-01, Vol.86, p.107-118
Main Authors: Mendoza, A., Zonja, B., Mastroianni, N., Negreira, N., López de Alda, M., Pérez, S., Barceló, D., Gil, A., Valcárcel, Y.
Format: Article
Language:English
Subjects:
Anti-cancer drugs
Chromatography, Liquid
Contrast Media - analysis
Cytostatic Agents - analysis
Drinking water
Drinking Water - analysis
Drinking Water - standards
Environmental Monitoring - methods
Human health risk characterization
Humans
Illicit drugs
Iodobenzoates - analysis
Mass Spectrometry
Pharmaceuticals
Public Health
Risk Assessment
Solid Phase Extraction
Spain
Street Drugs - analysis
Water Pollutants, Chemical - analysis
Water Purification - methods
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Summary:This work analyses the presence of forty-eight emerging pollutants, including twenty-five drugs of abuse and metabolites, seventeen cytostatic drugs and six iodinated contrast media, in tap water from the Madrid Region. Analysis of the target compounds in the tap water was performed by means of (on-line or off-line) solid-phase extraction followed by analysis by liquid chromatography–tandem mass spectrometry. A preliminary human health risk characterization was undertaken for each individual compound and for different groups of compounds with a common mechanism of action found in tap water. The results of the study showed the presence of eight out of the twenty-five drugs of abuse and metabolites analysed, namely, the cocainics cocaine and benzoylecgonine, the amphetamine-type stimulants ephedrine, 3,4-methylenedioxymethamphetamine and methamphetamine, the opioid methadone and its metabolite 2-ethylene-1,5-dimethyl-3,3-diphenylpyrrolidine and, finally caffeine at concentrations ranging from 0.11 to 502ngL−1. Four out of the six analysed iodinated contrast media, namely, diatrizoate, iohexol, iomeprol and iopromide, were detected in at least one sample, with concentration values varying between 0.4 and 5ngL−1. Cytostatic compounds were not detected in any sample. Caffeine was the substance showing the highest concentrations, up to 502ngL−1, mainly in the drinking water sampling point located in Madrid city. Among the other drugs of abuse, the most abundant compounds were cocaine and benzoylecgonine, detected at concentrations ranging from 0.11 to 86ngL−1 and from 0.11 to 53ngL−1, respectively. Regarding iodinated contrast media, iohexol was the most ubiquitous and abundant compound, with a frequency of detection of 100% and concentrations from 0.5 to 5.0ngL−1 in basically the same range in all sampling points. Taking into account the results and types of treatment applied, ozonisation plus granular activated carbon filtration appears to be efficient in the removal of cocaine and benzoylecgonine. For the amphetamine-type stimulants, opioids and caffeine, ozonisation plus granular activated carbon filtration and ultrafiltration plus reverse osmosis showed higher removal efficiency than sand filtration. The human health risk characterization performed indicates that the lifetime consumption of the tap waters analysed has associated a negligible human health concern. •Drugs of abuse and iodinated contrast media were found in the tap water from Madrid.•Cytostati
ISSN:0160-4120
1873-6750
DOI:10.1016/j.envint.2015.11.001