Drug Conjugation to Cyclic Peptide-Polymer Self-Assembling Nanotubes

We show for the first time how polymeric nanotubes (NTs) based on self‐assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA‐C, a ruthenium‐based anticancer drug, was conjugated to a statistical co‐polymer based on poly(2‐hydroxyethyl acrylate) (pHEA) a...

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Bibliographic Details
Published in:Chemistry : a European journal 2014-09, Vol.20 (40), p.12745-12749
Main Authors: Blunden , Bianca M., Chapman, Robert, Danial, Maarten, Lu, Hongxu, Jolliffe, Katrina A., Perrier , Sébastien, Stenzel, Martina H.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cancer
Carriers
Cell Line, Tumor
Chemistry
Conjugates
Conjugation
Drug Carriers - chemistry
drug conjugation
Drugs
Female
Humans
Models, Molecular
Nanotubes
Nanotubes - chemistry
Nanotubes - ultrastructure
Organometallic Compounds - administration & dosage
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Ovarian Neoplasms - drug therapy
Peptides
Peptides, Cyclic - chemistry
Polyhydroxyethyl Methacrylate - analogs & derivatives
Polyhydroxyethyl Methacrylate - chemistry
R&D
Research & development
ruthenium
Ruthenium - administration & dosage
Ruthenium - chemistry
Ruthenium - pharmacology
Self assembly
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Summary:We show for the first time how polymeric nanotubes (NTs) based on self‐assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA‐C, a ruthenium‐based anticancer drug, was conjugated to a statistical co‐polymer based on poly(2‐hydroxyethyl acrylate) (pHEA) and poly(2‐chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self‐assembly into nanotubes (length 200–500 nm) led to structures exhibiting high activity against cancer cells. Polymeric nanotubes (NTs) based on self‐assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier for RAPTA‐C, a ruthenium‐based anticancer drug. The drug was conjugated to a water‐soluble polymer, which formed the shell of the NTs. The self‐assembled nanotubes (ca. 200–500 nm in length) had a significant activity against cancer cells (see figure).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201403130