Electrochemical Synthesis of Benzazoles from Alcohols and o-Substituted Anilines with a Catalytic Amount of Co(II) Salt

An electrochemical synthesis of benzazoles directly from alcohols and o-substituted anilines has been developed. The reaction conditions have been optimized by varying the composition of the electrolyte and the metal salt used as catalyst. The cyclization proceeds smoothly with a catalytic amount of...

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Bibliographic Details
Published in:Chemistry : a European journal 2016-04, Vol.22 (15), p.5425-5429
Main Authors: Lai, Yin-Long, Ye, Jian-Shan, Huang, Jing-Mei
Format: Article
Language:English
Online Access:Get full text
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Summary:An electrochemical synthesis of benzazoles directly from alcohols and o-substituted anilines has been developed. The reaction conditions have been optimized by varying the composition of the electrolyte and the metal salt used as catalyst. The cyclization proceeds smoothly with a catalytic amount of a cobalt salt under air at room temperature to afford 2-substituted benzimidazoles, benzothiazoles, and benzoxazoles in good to excellent yields with a wide substrate scope.
ISSN:1521-3765
DOI:10.1002/chem.201505074