Danhong huayu koufuye prevents deep vein thrombosis through anti-inflammation in rats

Abstract Background Danhong huayu koufuye (DHK) has traditionally been used clinically for a long time in China. This study was to evaluate the effect of DHK in treating deep vein thrombosis (DVT) in rats and explore its possible mechanism. Methods Forty-eight Sprague–Dawley rats were divided into f...

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Published in:The Journal of surgical research 2016-04, Vol.201 (2), p.340-347
Main Authors: Zhang, Ziyang, MD, Hu, Luyun, MD, Chen, Wenpei, MD, Zhou, Chenghao, MD, Gui, Gang, BD, Lin, Baoqin, PhD
Format: Article
Language:English
Subjects:
Animals
Anti-inflammation
Blood Cell Count
Blood Coagulation - drug effects
Danhong huayu koufuye
Deep vein thrombosis
Drug Evaluation, Preclinical
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Inferior vena cava ligation
Interleukin-6 - blood
Male
Matrix Metalloproteinase 9 - metabolism
Matrix metalloproteinases
Random Allocation
Rats, Sprague-Dawley
Surgery
Thromboplastin - metabolism
Tissue factor
Tumor Necrosis Factor-alpha - blood
Vena Cava, Inferior - drug effects
Vena Cava, Inferior - pathology
Venous Thrombosis - metabolism
Venous Thrombosis - pathology
Venous Thrombosis - prevention & control
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Summary:Abstract Background Danhong huayu koufuye (DHK) has traditionally been used clinically for a long time in China. This study was to evaluate the effect of DHK in treating deep vein thrombosis (DVT) in rats and explore its possible mechanism. Methods Forty-eight Sprague–Dawley rats were divided into four groups, performed with incomplete inferior vena cava ligation to induce DVT, and orally administered with DHK (3.20 mg/kg/d), warfarin (2.00 mg/kg/d), or vehicle for 7 days. The involved inferior vena cava and thrombi were collected and measured in size. The tissue specimens were performed for routine histopathologic evaluation and immunohistochemical staining with tissue factor and matrix metalloproteinases-9. Blood samples were collected for detecting coagulation function, blood cell count, and the levels of interleukin-6 and tumor necrosis factor-α. Results The treatment of DHK markedly reduced the size of thrombi by 49.26%, and the vein wall thickness by 47.86%. The recanalization rate was significant higher in the DHK-treated group than the vehicle-treated group (26.34 ± 6.53% versus 15.91 ± 3.93%, P  
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2015.11.008