Myelin and oligodendrocyte development in the canine spinal cord

ABSTRACT We studied the developmental pattern of oligodendrocyte differentiation and myelin formation in the fetal canine spinal cord from E40 to P0. The pattern of development matches what has been described in the spinal cord of humans, rodents, and many other species. Oligodendrocytes were first...

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Bibliographic Details
Published in:Journal of comparative neurology (1911) 2016-04, Vol.524 (5), p.930-939
Main Authors: Mayer, Joshua A., Figari, Carlos, Radcliff, Abigail B., Mckee, Camille, Duncan, Ian D.
Format: Article
Language:English
Subjects:
Animals
dog cord
Dogs
gliogenesis
Humans
Myelin Sheath - physiology
myelination
Neurogenesis - physiology
Oligodendroglia - physiology
Spinal Cord - cytology
Spinal Cord - embryology
Spinal Cord - physiology
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Summary:ABSTRACT We studied the developmental pattern of oligodendrocyte differentiation and myelin formation in the fetal canine spinal cord from E40 to P0. The pattern of development matches what has been described in the spinal cord of humans, rodents, and many other species. Oligodendrocytes were first found at E40, close to the central canal, with their spread in a tangential manner to the ventral and then lateral columns. Myelin development followed the same pattern but was not seen until E46. A clear subpial zone lacking glial cells and myelin was seen in the lateral column in early development, suggesting that there may also be a radial component of migration of oligodendrocyte progenitor cells (OPCs) from a ventral site. This spatial–temporal developmental pattern seen in wild type matches a delay in myelination of the superficial tracts of the spinal cord seen in a canine myelin mutant, suggesting that the mutation prevents the distribution and differentiation of OPCs at an early, but narrow, window of time during fetal development. J. Comp. Neurol. 524:930–939, 2016. © 2015 Wiley Periodicals, Inc. We mapped the differentiation of oligodendrocytes and the development of myelin in the developing canine spinal cord and showed a similar pattern to that described in other species. A glial free zone, in the lateral cord, not previously described, provides clues to the pattern of migration of oligodendrocyte progenitors.
ISSN:0021-9967
1096-9861
DOI:10.1002/cne.23882