Twenty years of bacterial genome sequencing

Twenty years ago, the publication of the first bacterial genome sequence, from Haemophilus influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades of bacterial genome sequencing, which have been marked by three revolutions: whole-genome shotgun sequencing, high...

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Bibliographic Details
Published in:Nature reviews. Microbiology 2015-12, Vol.13 (12), p.787-794
Main Authors: Loman, Nicholas J, Pallen, Mark J
Format: Article
Language:English
Subjects:
Bacteria
Bacterial genetics
DNA sequencing
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Genome, Bacterial
Genomics
Haemophilus influenzae
History, 20th Century
History, 21st Century
Humans
Molecular Epidemiology - history
Molecular Epidemiology - methods
Molecular Epidemiology - trends
Molecular Typing - history
Molecular Typing - methods
Molecular Typing - trends
Nucleotide sequencing
Sequence Analysis, DNA - history
Sequence Analysis, DNA - methods
Sequence Analysis, DNA - trends
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Summary:Twenty years ago, the publication of the first bacterial genome sequence, from Haemophilus influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades of bacterial genome sequencing, which have been marked by three revolutions: whole-genome shotgun sequencing, high-throughput sequencing and single-molecule long-read sequencing. We summarize the social history of sequencing and its impact on our understanding of the biology, diversity and evolution of bacteria, while also highlighting spin-offs and translational impact in the clinic. We look forward to a 'sequencing singularity', where sequencing becomes the method of choice for as-yet unthinkable applications in bacteriology and beyond.
ISSN:1740-1526
1740-1534
DOI:10.1038/nrmicro3565