Cognitive Deficits Correlate with White Matter Deterioration in Spinocerebellar Ataxia Type 2

Objectives: The aim of this study was to explore the relationship between cognitive and white matter deterioration in a group of participants with spinocerebellar ataxia type 2 (SCA2). Methods: Fourteen genetically confirmed participants with SCA2 and 14 aged-matched controls participated in the stu...

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Published in:Journal of the International Neuropsychological Society 2016-04, Vol.22 (4), p.486-491
Main Authors: Hernandez-Castillo, Carlos R., Vaca-Palomares, Israel, Galvez, Víctor, Campos-Romo, Aurelio, Diaz, Rosalinda, Fernandez-Ruiz, Juan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Ataxia
Brief Communication
Case-Control Studies
Cognition Disorders - diagnostic imaging
Cognition Disorders - etiology
Diffusion Tensor Imaging
Disease
Female
Humans
Image Processing, Computer-Assisted
Leukoencephalopathies - diagnostic imaging
Leukoencephalopathies - etiology
Male
Memory
Middle Aged
Neuropsychological Tests
Severity of Illness Index
Spinocerebellar Ataxias - complications
Spinocerebellar Ataxias - pathology
Statistics as Topic
White Matter - diagnostic imaging
Young Adult
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Summary:Objectives: The aim of this study was to explore the relationship between cognitive and white matter deterioration in a group of participants with spinocerebellar ataxia type 2 (SCA2). Methods: Fourteen genetically confirmed participants with SCA2 and 14 aged-matched controls participated in the study. Diffusion tensor imaging tract-based spatial statistics were performed to analyze structural white matter integrity. Significant group differences in the mean diffusivity were correlated with SCA2 cognitive deficits. Results: Our analysis revealed higher mean diffusivity in the SCA2 group in cerebellar white matter, medial lemniscus, and middle cerebellar peduncle, among other regions. Cognitive scores correlated with white matter mean diffusivity in the parahippocampal area, inferior frontal and supramarginal gyri and the stria terminalis. Conclusions: Our findings show significant correlations between white matter microstructural damage in key areas affected in SCA2 and cognitive deficits. These findings result in a more comprehensive understanding of the effect of the neurodegenerative process in people with SCA2. (JINS, 2016, 22, 486–491)
ISSN:1355-6177
1469-7661
DOI:10.1017/S1355617716000084