B cell activating factor and T-helper 17 cells: possible synergistic culprits in the pathogenesis of Alopecia Areata

The role of T-helper 17 cells (Th17) and regulatory T-cells (Tregs) in the pathogenesis of alopecia areata (AA) has not been clearly elucidated. B cell activating factor (BAFF) being a regulator of T cell activation could be involved in this pathologic process as well. The current study evaluated th...

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Bibliographic Details
Published in:Archives of Dermatological Research 2016-03, Vol.308 (2), p.115-121
Main Authors: Elela, Mostafa A., Gawdat, Heba I., Hegazy, Rehab A., Fawzy, Marwa M., Abdel Hay, Rania M., Saadi, Dina, Shaker, Olfat
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alopecia Areata - immunology
Alopecia Areata - pathology
B-Cell Activating Factor - blood
Case-Control Studies
Dermatology
Enzyme-Linked Immunosorbent Assay
Female
Forkhead Transcription Factors - blood
Forkhead Transcription Factors - metabolism
Hair Follicle - immunology
Hair Follicle - pathology
Humans
Interleukin-17 - blood
Interleukin-17 - metabolism
Interleukin-22
Interleukins - blood
Interleukins - metabolism
Lymphocyte Activation - immunology
Male
Medicine
Medicine & Public Health
Middle Aged
Original Paper
T-Lymphocytes, Regulatory - immunology
Th17 Cells - immunology
Young Adult
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Summary:The role of T-helper 17 cells (Th17) and regulatory T-cells (Tregs) in the pathogenesis of alopecia areata (AA) has not been clearly elucidated. B cell activating factor (BAFF) being a regulator of T cell activation could be involved in this pathologic process as well. The current study evaluated the expression of IL-17, IL-22, Foxp3 and BAFF in tissue and sera of AA patients. Forty AA patients and 40 age and sex matched healthy controls were included. Tissue and serum levels of IL-17, IL-22, BAFF as well as serum level of Foxp3 were measured by enzyme-linked immunosorbent assay (ELISA). Immunohistochemical staining was used for assessment of tissue level of Foxp3. Tissue and serum levels of IL-17, tissue levels of IL-22 and BAFF were significantly higher in patients. Serum levels of IL-22, Foxp3 and BAFF were non-significantly higher in patients. Foxp3 immunostaining showed negativity in tissue of patients and controls. A significant positive correlation was found between both tissue levels of IL-17 and BAFF ( r  = 0.474, P  = 0.035) and tissue level of IL-22 and disease duration ( r  = 0.766, P  
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-016-1617-z