Carbapenem-Sparing Antibiotic Regimens for Infections Caused by Klebsiella pneumoniae Carbapenemase—Producing K. pneumoniae in Intensive Care Unit

A carbapenem-sparing regimen of tigecycline plus gentamicin or colistin was effective for treating 24 of 26 (92%) Klebsiella pneumoniae carbapenemase—producing K. pneumoniae infectious episodes in 22 polytrauma intensive care unit patients without comorbidities. The 30-day crude mortality rate was 1...

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Bibliographic Details
Published in:Clinical infectious diseases 2013-03, Vol.56 (5), p.697-700
Main Authors: Sbrana, Francesco, Malacarne, Paolo, Viaggi, Bruno, Costanzo, Sergio, Leonetti, Piero, Leonildi, Alessandro, Casini, Beatrice, Tascini, Carlo, Menichetti, Francesco
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobials
Bacterial Proteins - metabolism
beta-Lactamases - metabolism
Biological and medical sciences
BRIEF REPORTS
Carbapenems
Carbapenems - therapeutic use
Colistin - therapeutic use
Drug Therapy, Combination
Female
Gentamicins - therapeutic use
Gram-negative bacteria
Humans
Infections
Infectious diseases
Intensive care
Intensive Care Units
Klebsiella Infections - drug therapy
Klebsiella Infections - microbiology
Klebsiella pneumoniae
Klebsiella pneumoniae - enzymology
Male
Medical sciences
Middle Aged
Minocycline - analogs & derivatives
Minocycline - therapeutic use
Mortality
Nosocomial infections
Pharmacology. Drug treatments
Retrospective Studies
Sepsis
Septic shock
Treatment Outcome
Urinary tract infections
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Summary:A carbapenem-sparing regimen of tigecycline plus gentamicin or colistin was effective for treating 24 of 26 (92%) Klebsiella pneumoniae carbapenemase—producing K. pneumoniae infectious episodes in 22 polytrauma intensive care unit patients without comorbidities. The 30-day crude mortality rate was 14%. Regimens were considered appropriate in 12% of episodes according to the Vitek 2 System and in 100% based on E-test.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cis969