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Immunolocalization of connexin 26 in the developing mouse cochlea
Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell–cell communication. In this study, we demonstrate the temporal–spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction...
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Published in: | Brain Research Reviews 2000-04, Vol.32 (1), p.172-180 |
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description | Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell–cell communication. In this study, we demonstrate the temporal–spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction protein to specific cochlear structures, including the inner and outer sulcus cells, the supporting cells of the inner hair cells, the mesenchyme derived portion of the stria vascularis, and the cells of the spiral ligament that interface with the basal cells of the stria vascularis. This suggests that this gap junction protein of served patterns of connexin 26 distribution is important for the differentiation and development of these structures (e.g., the role of the inner sulcus cells in producing the tectorial membrane). |
doi_str_mv | 10.1016/S0165-0173(99)00078-8 |
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subjects | Biological and medical sciences Cochlea Connexin 26 Development Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Fundamental and applied biological sciences. Psychology Gap junction inner sulcus cells tectorial membrane Vertebrates: nervous system and sense organs |
title | Immunolocalization of connexin 26 in the developing mouse cochlea |
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