Immunolocalization of connexin 26 in the developing mouse cochlea

Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell–cell communication. In this study, we demonstrate the temporal–spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction...

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Bibliographic Details
Published in:Brain Research Reviews 2000-04, Vol.32 (1), p.172-180
Main Authors: Frenz, Christopher M, Van De Water, Thomas R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cochlea
Connexin 26
Development
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Fundamental and applied biological sciences. Psychology
Gap junction
inner sulcus cells
tectorial membrane
Vertebrates: nervous system and sense organs
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Summary:Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell–cell communication. In this study, we demonstrate the temporal–spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction protein to specific cochlear structures, including the inner and outer sulcus cells, the supporting cells of the inner hair cells, the mesenchyme derived portion of the stria vascularis, and the cells of the spiral ligament that interface with the basal cells of the stria vascularis. This suggests that this gap junction protein of served patterns of connexin 26 distribution is important for the differentiation and development of these structures (e.g., the role of the inner sulcus cells in producing the tectorial membrane).
ISSN:0165-0173
1872-6321
DOI:10.1016/S0165-0173(99)00078-8