Effects of NO Donors and Inhibitors of NO Synthase and Guanylate Cyclase on the Acquisition of a Conditioned Defense Food Aversion Response in Edible Snails

Experiments on edible snails revealed that NO synthase blockade with a nonspecific neuronal NO synthase inhibitor L-NAME before defense food aversion conditioning is followed by a decrease in the rate of learning. Exogenous NO donors, sodium nitroprusside and dinitrosyl iron complex, were shown to i...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-02, Vol.160 (4), p.414-416
Main Authors: Muranova, L. N., Bogodvid, T. Kh, Andrianov, V. V., Gainutdinov, Kh. L.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Conditioning (Psychology) - drug effects
Enzyme Inhibitors - pharmacology
Guanylate Cyclase - antagonists & inhibitors
Internal Medicine
Iron - chemistry
Laboratory Medicine
Learning - drug effects
NG-Nitroarginine Methyl Ester - pharmacology
Nitric Oxide - chemistry
Nitric Oxide Synthase - antagonists & inhibitors
Nitrogen Oxides - chemistry
Nitroprusside - chemistry
Oxadiazoles - pharmacology
Pathology
Quinoxalines - pharmacology
Shellfish
Snails
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Summary:Experiments on edible snails revealed that NO synthase blockade with a nonspecific neuronal NO synthase inhibitor L-NAME before defense food aversion conditioning is followed by a decrease in the rate of learning. Exogenous NO donors, sodium nitroprusside and dinitrosyl iron complex, were shown to improve learning. Chronic administration of a specific soluble guanylate cyclase inhibitor ODQ also increased the rate of learning. Our results indicate that NO has a modulatory effect on the formation of a conditioned response in this type of learning.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3184-x