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Biphasic cardiovascular and respiratory effects induced by β-citronellol
β-Citronellol is a monoterpene found in the essential oil of various plants with antihypertensive properties. In fact, β-citronellol possesses hypotensive actions due to its vasodilator abilities. Here we aimed to show that β-citronellol recruits airway sensory neural circuitry to evoke cardiorespir...
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| Published in: | European journal of pharmacology 2016-03, Vol.775, p.96-105 |
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| container_title | European journal of pharmacology |
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| creator | Ribeiro-Filho, Helder Veras de Souza Silva, Camila Meirelles de Siqueira, Rodrigo JoséBezerra Lahlou, Saad dos Santos, Armênio Aguiar Magalhães, Pedro Jorge Caldas |
| description | β-Citronellol is a monoterpene found in the essential oil of various plants with antihypertensive properties. In fact, β-citronellol possesses hypotensive actions due to its vasodilator abilities. Here we aimed to show that β-citronellol recruits airway sensory neural circuitry to evoke cardiorespiratory effects. In anesthetized rats, intravenous injection of β-citronellol caused biphasic hypotension, bradycardia and apnea. Bilateral vagotomy, perivagal capsaicin treatment or injection into the left ventricle abolished first rapid phase (named P1) but not delayed phase P2 of the β-citronellol effects. P1 persisted after pretreatment with capsazepine, ondansetron, HC-030031 or suramin. Suramin abolished P2 of apnea. In awake rats, β-citronellol induced biphasic hypotension and bradycardia being P1 abolished by methylatropine. In vitro, β-citronellol inhibited spontaneous or electrically-evoked contractions of rat isolated right or left atrium, respectively, and fully relaxed sustained contractions of phenylephrine in mesenteric artery rings. In conclusion, chemosensitive pulmonary vagal afferent fibers appear to mediate the cardiovascular and respiratory effects of β-citronellol. The transduction mechanism in P1 seems not to involve the activation of transient receptor potential vanilloid subtype 1 (TRPV1), transient receptor potential ankyrin subtype 1 (TRPA1), purinergic (P2X) or 5-HT3 receptors located on airways sensory nerves. P2 of hypotension and bradycardia seems resulting from a cardioinhibitory and vasodilatory effect of β-citronellol and the apnea from a purinergic signaling. |
| doi_str_mv | 10.1016/j.ejphar.2016.02.025 |
| format | article |
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In fact, β-citronellol possesses hypotensive actions due to its vasodilator abilities. Here we aimed to show that β-citronellol recruits airway sensory neural circuitry to evoke cardiorespiratory effects. In anesthetized rats, intravenous injection of β-citronellol caused biphasic hypotension, bradycardia and apnea. Bilateral vagotomy, perivagal capsaicin treatment or injection into the left ventricle abolished first rapid phase (named P1) but not delayed phase P2 of the β-citronellol effects. P1 persisted after pretreatment with capsazepine, ondansetron, HC-030031 or suramin. Suramin abolished P2 of apnea. In awake rats, β-citronellol induced biphasic hypotension and bradycardia being P1 abolished by methylatropine. In vitro, β-citronellol inhibited spontaneous or electrically-evoked contractions of rat isolated right or left atrium, respectively, and fully relaxed sustained contractions of phenylephrine in mesenteric artery rings. In conclusion, chemosensitive pulmonary vagal afferent fibers appear to mediate the cardiovascular and respiratory effects of β-citronellol. The transduction mechanism in P1 seems not to involve the activation of transient receptor potential vanilloid subtype 1 (TRPV1), transient receptor potential ankyrin subtype 1 (TRPA1), purinergic (P2X) or 5-HT3 receptors located on airways sensory nerves. P2 of hypotension and bradycardia seems resulting from a cardioinhibitory and vasodilatory effect of β-citronellol and the apnea from a purinergic signaling.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2016.02.025</identifier><identifier>PMID: 26872991</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Apnea - chemically induced ; Apnea - physiopathology ; Arterial Pressure - drug effects ; Atrial Function - drug effects ; Bradycardia - chemically induced ; Bradycardia - physiopathology ; Heart Rate - drug effects ; Hypotension - chemically induced ; Hypotension - physiopathology ; Male ; Mesenteric Arteries - drug effects ; Mesenteric Arteries - physiology ; Monoterpenes - pharmacology ; Perineural capsaicin pretreatment ; Rats, Wistar ; Respiratory Rate - drug effects ; Sensory C-fibers ; Vago-vagal reflex ; Vagotomy ; Vagus Nerve - drug effects ; Vagus Nerve - physiology ; Vascular smooth muscle ; β-Citronellol</subject><ispartof>European journal of pharmacology, 2016-03, Vol.775, p.96-105</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-e532ecfe4f0749a4c588d92c80c78fd2fe22a0bb5133ab80c723533b63a42aca3</citedby><cites>FETCH-LOGICAL-c408t-e532ecfe4f0749a4c588d92c80c78fd2fe22a0bb5133ab80c723533b63a42aca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26872991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribeiro-Filho, Helder Veras</creatorcontrib><creatorcontrib>de Souza Silva, Camila Meirelles</creatorcontrib><creatorcontrib>de Siqueira, Rodrigo JoséBezerra</creatorcontrib><creatorcontrib>Lahlou, Saad</creatorcontrib><creatorcontrib>dos Santos, Armênio Aguiar</creatorcontrib><creatorcontrib>Magalhães, Pedro Jorge Caldas</creatorcontrib><title>Biphasic cardiovascular and respiratory effects induced by β-citronellol</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>β-Citronellol is a monoterpene found in the essential oil of various plants with antihypertensive properties. In fact, β-citronellol possesses hypotensive actions due to its vasodilator abilities. Here we aimed to show that β-citronellol recruits airway sensory neural circuitry to evoke cardiorespiratory effects. In anesthetized rats, intravenous injection of β-citronellol caused biphasic hypotension, bradycardia and apnea. Bilateral vagotomy, perivagal capsaicin treatment or injection into the left ventricle abolished first rapid phase (named P1) but not delayed phase P2 of the β-citronellol effects. P1 persisted after pretreatment with capsazepine, ondansetron, HC-030031 or suramin. Suramin abolished P2 of apnea. In awake rats, β-citronellol induced biphasic hypotension and bradycardia being P1 abolished by methylatropine. In vitro, β-citronellol inhibited spontaneous or electrically-evoked contractions of rat isolated right or left atrium, respectively, and fully relaxed sustained contractions of phenylephrine in mesenteric artery rings. In conclusion, chemosensitive pulmonary vagal afferent fibers appear to mediate the cardiovascular and respiratory effects of β-citronellol. The transduction mechanism in P1 seems not to involve the activation of transient receptor potential vanilloid subtype 1 (TRPV1), transient receptor potential ankyrin subtype 1 (TRPA1), purinergic (P2X) or 5-HT3 receptors located on airways sensory nerves. P2 of hypotension and bradycardia seems resulting from a cardioinhibitory and vasodilatory effect of β-citronellol and the apnea from a purinergic signaling.</description><subject>Animals</subject><subject>Apnea - chemically induced</subject><subject>Apnea - physiopathology</subject><subject>Arterial Pressure - drug effects</subject><subject>Atrial Function - drug effects</subject><subject>Bradycardia - chemically induced</subject><subject>Bradycardia - physiopathology</subject><subject>Heart Rate - drug effects</subject><subject>Hypotension - chemically induced</subject><subject>Hypotension - physiopathology</subject><subject>Male</subject><subject>Mesenteric Arteries - drug effects</subject><subject>Mesenteric Arteries - physiology</subject><subject>Monoterpenes - pharmacology</subject><subject>Perineural capsaicin pretreatment</subject><subject>Rats, Wistar</subject><subject>Respiratory Rate - drug effects</subject><subject>Sensory C-fibers</subject><subject>Vago-vagal reflex</subject><subject>Vagotomy</subject><subject>Vagus Nerve - drug effects</subject><subject>Vagus Nerve - physiology</subject><subject>Vascular smooth muscle</subject><subject>β-Citronellol</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kM1KxDAQx4Mo7rr6BiI9euk6ST-SXgRd_FhY8KLnkKYTTOm2NWmFfS0fxGcyS1ePwsAww3_mP_Mj5JLCkgLNb-ol1v27cksWqiWwENkRmVPBixg4ZcdkDkDTmBVFMSNn3tcAkBUsOyUzlgse-nRO1vc2LPFWR1q5ynafyuuxUS5SbRU59L11aujcLkJjUA8-sm01aqyichd9f8XaDq5rsWm65pycGNV4vDjkBXl7fHhdPcebl6f16m4T6xTEEGOWMNQGUwM8LVSqMyGqgmkBmgtTMYOMKSjLjCaJKvddlmRJUuaJSpnSKlmQ62lv77qPEf0gt9brcIJqsRu9pJyD4Hme0yBNJ6l2nfcOjeyd3Sq3kxTkHqKs5QRR7iFKYCGyMHZ1cBjLLVZ_Q7_UguB2EmD489Oik15bbAMW6wIkWXX2f4cfAFuGRQ</recordid><startdate>20160315</startdate><enddate>20160315</enddate><creator>Ribeiro-Filho, Helder Veras</creator><creator>de Souza Silva, Camila Meirelles</creator><creator>de Siqueira, Rodrigo JoséBezerra</creator><creator>Lahlou, Saad</creator><creator>dos Santos, Armênio Aguiar</creator><creator>Magalhães, Pedro Jorge Caldas</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160315</creationdate><title>Biphasic cardiovascular and respiratory effects induced by β-citronellol</title><author>Ribeiro-Filho, Helder Veras ; 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In fact, β-citronellol possesses hypotensive actions due to its vasodilator abilities. Here we aimed to show that β-citronellol recruits airway sensory neural circuitry to evoke cardiorespiratory effects. In anesthetized rats, intravenous injection of β-citronellol caused biphasic hypotension, bradycardia and apnea. Bilateral vagotomy, perivagal capsaicin treatment or injection into the left ventricle abolished first rapid phase (named P1) but not delayed phase P2 of the β-citronellol effects. P1 persisted after pretreatment with capsazepine, ondansetron, HC-030031 or suramin. Suramin abolished P2 of apnea. In awake rats, β-citronellol induced biphasic hypotension and bradycardia being P1 abolished by methylatropine. In vitro, β-citronellol inhibited spontaneous or electrically-evoked contractions of rat isolated right or left atrium, respectively, and fully relaxed sustained contractions of phenylephrine in mesenteric artery rings. In conclusion, chemosensitive pulmonary vagal afferent fibers appear to mediate the cardiovascular and respiratory effects of β-citronellol. The transduction mechanism in P1 seems not to involve the activation of transient receptor potential vanilloid subtype 1 (TRPV1), transient receptor potential ankyrin subtype 1 (TRPA1), purinergic (P2X) or 5-HT3 receptors located on airways sensory nerves. P2 of hypotension and bradycardia seems resulting from a cardioinhibitory and vasodilatory effect of β-citronellol and the apnea from a purinergic signaling.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26872991</pmid><doi>10.1016/j.ejphar.2016.02.025</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of pharmacology, 2016-03, Vol.775, p.96-105 |
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| source | ScienceDirect Freedom Collection |
| subjects | Animals Apnea - chemically induced Apnea - physiopathology Arterial Pressure - drug effects Atrial Function - drug effects Bradycardia - chemically induced Bradycardia - physiopathology Heart Rate - drug effects Hypotension - chemically induced Hypotension - physiopathology Male Mesenteric Arteries - drug effects Mesenteric Arteries - physiology Monoterpenes - pharmacology Perineural capsaicin pretreatment Rats, Wistar Respiratory Rate - drug effects Sensory C-fibers Vago-vagal reflex Vagotomy Vagus Nerve - drug effects Vagus Nerve - physiology Vascular smooth muscle β-Citronellol |
| title | Biphasic cardiovascular and respiratory effects induced by β-citronellol |
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