Biphasic cardiovascular and respiratory effects induced by β-citronellol

β-Citronellol is a monoterpene found in the essential oil of various plants with antihypertensive properties. In fact, β-citronellol possesses hypotensive actions due to its vasodilator abilities. Here we aimed to show that β-citronellol recruits airway sensory neural circuitry to evoke cardiorespir...

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Bibliographic Details
Published in:European journal of pharmacology 2016-03, Vol.775, p.96-105
Main Authors: Ribeiro-Filho, Helder Veras, de Souza Silva, Camila Meirelles, de Siqueira, Rodrigo JoséBezerra, Lahlou, Saad, dos Santos, Armênio Aguiar, Magalhães, Pedro Jorge Caldas
Format: Article
Language:English
Subjects:
Animals
Apnea - chemically induced
Apnea - physiopathology
Arterial Pressure - drug effects
Atrial Function - drug effects
Bradycardia - chemically induced
Bradycardia - physiopathology
Heart Rate - drug effects
Hypotension - chemically induced
Hypotension - physiopathology
Male
Mesenteric Arteries - drug effects
Mesenteric Arteries - physiology
Monoterpenes - pharmacology
Perineural capsaicin pretreatment
Rats, Wistar
Respiratory Rate - drug effects
Sensory C-fibers
Vago-vagal reflex
Vagotomy
Vagus Nerve - drug effects
Vagus Nerve - physiology
Vascular smooth muscle
β-Citronellol
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Summary:β-Citronellol is a monoterpene found in the essential oil of various plants with antihypertensive properties. In fact, β-citronellol possesses hypotensive actions due to its vasodilator abilities. Here we aimed to show that β-citronellol recruits airway sensory neural circuitry to evoke cardiorespiratory effects. In anesthetized rats, intravenous injection of β-citronellol caused biphasic hypotension, bradycardia and apnea. Bilateral vagotomy, perivagal capsaicin treatment or injection into the left ventricle abolished first rapid phase (named P1) but not delayed phase P2 of the β-citronellol effects. P1 persisted after pretreatment with capsazepine, ondansetron, HC-030031 or suramin. Suramin abolished P2 of apnea. In awake rats, β-citronellol induced biphasic hypotension and bradycardia being P1 abolished by methylatropine. In vitro, β-citronellol inhibited spontaneous or electrically-evoked contractions of rat isolated right or left atrium, respectively, and fully relaxed sustained contractions of phenylephrine in mesenteric artery rings. In conclusion, chemosensitive pulmonary vagal afferent fibers appear to mediate the cardiovascular and respiratory effects of β-citronellol. The transduction mechanism in P1 seems not to involve the activation of transient receptor potential vanilloid subtype 1 (TRPV1), transient receptor potential ankyrin subtype 1 (TRPA1), purinergic (P2X) or 5-HT3 receptors located on airways sensory nerves. P2 of hypotension and bradycardia seems resulting from a cardioinhibitory and vasodilatory effect of β-citronellol and the apnea from a purinergic signaling.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2016.02.025