Involvement of dorsal striatal α1-containing GABAA receptors in methamphetamine-associated rewarding memories

Highlights • GABAA α1 subunit was down-regulated in the Dstr but not other regions in METH CPP. • Expression of GABAA α1 was related to METH rewarding memory but not drug effect. • Activation of α1-containing GABAA receptors in the Dstr abolished METH CPP.

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Bibliographic Details
Published in:Neuroscience 2016-04, Vol.320, p.230-238
Main Authors: Jiao, D.-L, Liu, Y, Long, J.-D, Du, J, Ju, Y.-Y, Zan, G.-Y, Liu, J.-G, Zhao, M
Format: Article
Language:English
Subjects:
Amphetamine-Related Disorders - metabolism
Animals
Blotting, Western
Central Nervous System Stimulants - pharmacology
conditioned place preference
Conditioning, Operant
Corpus Striatum - metabolism
dorsal striatum
GABAAα1
Male
Memory
methamphetamine
Methamphetamine - pharmacology
Neurology
Rats
Rats, Sprague-Dawley
Receptors, GABA-A - metabolism
Reward
rewarding memories
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Description
Summary:Highlights • GABAA α1 subunit was down-regulated in the Dstr but not other regions in METH CPP. • Expression of GABAA α1 was related to METH rewarding memory but not drug effect. • Activation of α1-containing GABAA receptors in the Dstr abolished METH CPP.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.02.001