The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough

Desulfovibrio vulgaris Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome...

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Bibliographic Details
Published in:Nature biotechnology 2004-05, Vol.22 (5), p.554-559
Main Authors: Heidelberg, John F, Seshadri, Rekha, Haveman, Shelley A, Hemme, Christopher L, Paulsen, Ian T, Kolonay, James F, Eisen, Jonathan A, Ward, Naomi, Methe, Barbara, Brinkac, Lauren M, Daugherty, Sean C, Deboy, Robert T, Dodson, Robert J, Durkin, A Scott, Madupu, Ramana, Nelson, William C, Sullivan, Steven A, Fouts, Derrick, Haft, Daniel H, Selengut, Jeremy, Peterson, Jeremy D, Davidsen, Tanja M, Zafar, Nikhat, Zhou, Liwei, Radune, Diana, Dimitrov, George, Hance, Mark, Tran, Kevin, Khouri, Hoda, Gill, John, Utterback, Terry R, Feldblyum, Tamara V, Wall, Judy D, Voordouw, Gerrit, Fraser, Claire M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biology of microorganisms of confirmed or potential industrial interest
Biotechnology
Desulfovibrio vulgaris
Desulfovibrio vulgaris - genetics
Desulfovibrio vulgaris - metabolism
Energy Metabolism
Fundamental and applied biological sciences. Psychology
Genetics
Genome, Bacterial
Mission oriented research
Molecular Sequence Data
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Summary:Desulfovibrio vulgaris Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome sequence reveals a network of novel c-type cytochromes, connecting multiple periplasmic hydrogenases and formate dehydrogenases, as a key feature of its energy metabolism. The relative arrangement of genes encoding enzymes for energy transduction, together with inferred cellular location of the enzymes, provides a basis for proposing an expansion to the 'hydrogen-cycling' model for increasing energy efficiency in this bacterium. Plasmid-encoded functions include modification of cell surface components, nitrogen fixation and a type-III protein secretion system. This genome sequence represents a substantial step toward the elucidation of pathways for reduction (and bioremediation) of pollutants such as uranium and chromium and offers a new starting point for defining this organism's complex anaerobic respiration.
ISSN:1087-0156
1546-1696
DOI:10.1038/nbt959