Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic resonance contrast agents

Abstract This work described a proof of concept study of hybrid nanogel-based magnetic resonance contrast agents, SPIO@GCS/acryl/biotin@Mn-gel, abb. as SGM, for highly efficient, pH-responsive T1 and T2 dual-mode magnetic resonance imaging (MRI). SGM have been synthesized by assembling superparamagn...

Full description

Saved in:
Bibliographic Details
Published in:Biomaterials 2015-06, Vol.53, p.349-357
Main Authors: Wang, Xia, Niu, Dechao, Wu, Qing, Bao, Song, Su, Teng, Liu, Xiaohang, Zhang, Shengjian, Wang, Qigang
Format: Article
Language:English
Subjects:
Acid-responsive
Advanced Basic Science
Animals
Biomedical materials
Contrast agents
Contrast Media
Dentistry
Female
Ferric Compounds - chemistry
Gels
Hep G2 Cells
Humans
Hydrogen-Ion Concentration
Magnetic resonance
Magnetic Resonance Imaging
Manganese Compounds - chemistry
Manganese species
Mice
Mice, Nude
Nanogel
Nanostructure
Nanotechnology
Oxides - chemistry
Superparamagnetic iron oxide particles
Surgical implants
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract This work described a proof of concept study of hybrid nanogel-based magnetic resonance contrast agents, SPIO@GCS/acryl/biotin@Mn-gel, abb. as SGM, for highly efficient, pH-responsive T1 and T2 dual-mode magnetic resonance imaging (MRI). SGM have been synthesized by assembling superparamagnetic iron oxide particles into polysaccharide nanoclusters, followed by in-situ reduction of the manganese species on the clusters and a final mild polymerization. The dual-mode SGM showed an interesting pH-responsiveness in in vitro MRI, with both T1 and T2 relaxivities turned “ON” in the acidic environment, along with an increase in the r1 and r2 relaxivity values by 1.7-fold (from 8.9 to 15.3 mM−1  S−1 ) and 4.9-fold (from 45.7 to 226 mM−1  S−1 ), due to desirable silencing and de-silencing effects. This interesting acidic-responsiveness was further verified in vivo with both significantly brightened signal of tumor tissue in T1 -weighted MR images and a darkened signal in T2 -weighted MR images 50 min post-injection of SGM. This smart hybrid nanogel may serve as a promising candidate for further studies of dual-mode (T1 and T2 ) contrast agents in MRI, due to its high stability, interesting pH-response mechanism and indicative imaging of tumors.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2015.02.101