Monitoring organic reactions by UF-NMR spectroscopy

Standard 2D NMR experiments suffer from the many t1 increments needed for spectra with sufficient digital resolution in the indirect dimension. Despite the different methodological approaches to overcome this problem, these increments have prevented studies of fast reactions. The development of ultr...

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Bibliographic Details
Published in:Magnetic resonance in chemistry 2015-11, Vol.53 (11), p.952-970
Main Authors: Herrera, Antonio, Fernández-Valle, Encarnación, Martínez-Álvarez, Roberto, Molero-Vílchez, Dolores, Pardo-Botero, Zulay D., Sáez-Barajas, Elena
Format: Article
Language:English
Subjects:
2D NMR spectroscopy
Chemical reactions
Dynamical systems
Dynamics
Monitoring
Nuclear magnetic resonance
Real time
real-time monitoring
Spectra
ultrafast NMR
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Summary:Standard 2D NMR experiments suffer from the many t1 increments needed for spectra with sufficient digital resolution in the indirect dimension. Despite the different methodological approaches to overcome this problem, these increments have prevented studies of fast reactions. The development of ultrafast NMR (UF‐NMR) has decisively speeded up the time scale of standard NMR to allow the study of organic reactions as they happen in real time to reveal mechanistic details. This mini‐review summarizes the results achieved in monitoring organic reactions through this exciting technique. Copyright © 2015 John Wiley & Sons, Ltd. Ultrafast NMR has undoubtedly opened up new perspectives in monitoring dynamic systems as they happen in real time. It has permitted to study in‐depth fast organic reactions and transient species participating in their mechanisms. In the present review are shown some results that highlight the potential of the methodology.
ISSN:0749-1581
1097-458X
DOI:10.1002/mrc.4240