Contrast Induced Nephropathy and Long-term Renal Decline After Percutaneous Transluminal Angioplasty for Symptomatic Peripheral Arterial Disease

Objective/background Administration of iodinated contrast media during endovascular procedures for peripheral arterial disease (PAD) may cause contrast induced nephropathy (CIN). The aim of the present study was to establish the incidence of CIN after these procedures and to study its association wi...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2016-03, Vol.51 (3), p.386-393
Main Authors: Sigterman, T.A, Krasznai, A.G, Snoeijs, M.G, Heijboer, R, Schurink, G.W.H, Bouwman, L.H
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Acute Kidney Injury - diagnosis
Acute Kidney Injury - epidemiology
Adult
Aged
Aged, 80 and over
Angioplasty - adverse effects
Cardiovascular events
Contrast induced nephropathy
Contrast Media - adverse effects
Endovascular interventions
Endovascular Procedures - adverse effects
Endovascular Procedures - methods
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Incidence
Intermittent Claudication - diagnostic imaging
Intermittent Claudication - therapy
Kidney - physiopathology
Male
Middle Aged
Mortality
Netherlands - epidemiology
Peripheral arterial disease
Peripheral Arterial Disease - diagnostic imaging
Peripheral Arterial Disease - therapy
Prognosis
Prospective Studies
Radiography
Renal decline
Risk Assessment - methods
Surgery
Survival Rate - trends
Time Factors
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Summary:Objective/background Administration of iodinated contrast media during endovascular procedures for peripheral arterial disease (PAD) may cause contrast induced nephropathy (CIN). The aim of the present study was to establish the incidence of CIN after these procedures and to study its association with long-term loss of kidney function, cardiovascular events, and death. Methods Consecutive patients first presenting with symptomatic PAD (Rutherford classification II–VI) who were treated with an endovascular procedure were included in this prospective observational cohort study. CIN was defined as >25% increase of serum creatinine concentration from baseline at 5 days after the intervention. Results Some 337 patients were included with a mean estimated glomerular filtration rate (eGFR) of 67 mL/minute. Thirteen percent (95% confidence interval [CI] 9–16) of these patients developed CIN after endovascular interventions for PAD. One year after treatment, eGFR was reduced by 12.4 mL/minute (95% CI 8.6–16.2) in patients with CIN compared with 6.2 mL/minute (95% CI 4.9–7.0) in patients without acute kidney injury ( p  
ISSN:1078-5884
1532-2165
DOI:10.1016/j.ejvs.2015.08.023