Longitudinal epitope mapping in MuSK myasthenia gravis: implications for disease severity

Abstract Muscle weakness in MuSK myasthenia gravis (MG) is caused predominantly by IgG4 antibodies which block MuSK signalling and destabilize neuromuscular junctions. We determined whether the binding pattern of MuSK IgG4 antibodies change throughout the disease course (“epitope spreading”), and af...

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Bibliographic Details

Published in:	Journal of neuroimmunology 2016-02, Vol.291, p.82-88
Main Authors:	Huijbers, Maartje G, Vink, Anna-Fleur D, Niks, Erik H, Westhuis, Ruben H, van Zwet, Erik W, de Meel, Robert H, Rojas-García, Ricardo, Díaz-Manera, Jordi, Kuks, Jan B, Klooster, Rinse, Straasheijm, Kirsten, Evoli, Amelia, Illa, Isabel, van der Maarel, Silvère M, Verschuuren, Jan J
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Allergy and Immunology Autoantibodies - blood Cholinesterase Inhibitors - therapeutic use Enzyme-Linked Immunosorbent Assay Epitope Mapping Female Humans IgG4 Italy Longitudinal Studies Male Middle Aged MuSK Myasthenia gravis Myasthenia Gravis - blood Myasthenia Gravis - drug therapy Myasthenia Gravis - immunology Neurology Neuromuscular junction Receptor Protein-Tyrosine Kinases - immunology Receptors, Cholinergic - immunology Severity of Illness Index Spain Statistics as Topic Young Adult
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