Low birth weight associates with hippocampal gene expression

Highlights • We compared hippocampal gene expression and DNA methylation between low and normal birth weight neonates. • Birth weight associated with genome-wide transcription in the hippocampus. • Differentially expressed genes were involved in neuronal projection. • Few genes with differential exp...

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Bibliographic Details
Published in:Neuroscience 2016-03, Vol.318, p.190-205
Main Authors: Buschdorf, J.P, Ong, M.L, Ong, S.X, MacIsaac, J.L, Chng, K, Kobor, M.S, Meaney, M.J, Holbrook, J.D
Format: Article
Language:English
Subjects:
Animals
DNA methylation
DNA Methylation - physiology
Epigenesis, Genetic - genetics
Female
Gene Expression - physiology
Gene Expression Profiling - methods
Gene Expression Regulation
hippocampus
Hippocampus - metabolism
Infant, Low Birth Weight
low birth weight
Macaca fascicularis
mental disorders
microarray
Neurology
Oligonucleotide Array Sequence Analysis - methods
Pregnancy
Risk
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Summary:Highlights • We compared hippocampal gene expression and DNA methylation between low and normal birth weight neonates. • Birth weight associated with genome-wide transcription in the hippocampus. • Differentially expressed genes were involved in neuronal projection. • Few genes with differential expression co-varied with DNA methylation levels. • Birth weight associates with hippocampal gene expression with a small epigenetic underpinning.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.01.013