Long‐term oral contraceptive use increases breast cancer risk in women over 55 years of age: The DOM cohort

The role of past oral contraceptive use in the development of breast cancer is unclear, particularly in postmenopausal women. The authors investigated this relationship among pre‐ and postmenopausal middle‐aged women in a nested case‐control study within the population‐based DOM cohort, Utrecht, the...

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Bibliographic Details
Published in:International journal of cancer 2000-08, Vol.87 (4), p.591-594
Main Authors: Van Hoften, Carlijn, Burger, Huibert, Peeters, Petra H.M., Grobbee, Diederick E., Van Noord, Paul A.H., Leufkens, Hubert G.M.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Biological and medical sciences
Breast Neoplasms - chemically induced
Cohort Studies
contraceptives
Contraceptives, Oral - adverse effects
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Middle Aged
post-menopause
Postmenopause
Premenopause
Risk Factors
Time Factors
Tumors
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Summary:The role of past oral contraceptive use in the development of breast cancer is unclear, particularly in postmenopausal women. The authors investigated this relationship among pre‐ and postmenopausal middle‐aged women in a nested case‐control study within the population‐based DOM cohort, Utrecht, the Netherlands. Among a total population of 12,184 women followed up for an average of 7.5 years, 309 breast cancer cases aged 42 to 63 years, diagnosed from November 1982 through May 1996, and 610 controls were examined. Overall, duration of oral contraceptive use was not clearly related to breast cancer. In women older than 55 years, however, oral contraceptive use for more than 10 years was associated with a 2‐fold increased risk of breast cancer (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.1–4.0). We conclude that long duration of oral contraceptive use increases the risk of breast cancer in women over 55 years of age but not in younger women. Int. J. Cancer 87:591–594, 2000. © 2000 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/1097-0215(20000815)87:4<591::AID-IJC20>3.0.CO;2-C