Endothelin-1-induced remodelling of murine adult ventricular myocytes

Graphical abstract Chronic stimulation of rat adult cardiomyocytes with hormones signalling through Gq proteins induces cellular remodelling associated with increased arrhythmogenicity (ECT-extra calcium transients) (A), malfunctional calcium handling (B) and altered gene expression (DIV-days in vit...

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Bibliographic Details
Published in:Cell calcium (Edinburgh) 2016-01, Vol.59 (1), p.41-53
Main Authors: Viero, Cedric, Wegener, Silke, Scholz, Anke, Ruppenthal, Sandra, Tian, Qinghai, Tabellion, Wiebke, Kreinest, Michael, Laschke, Matthias W, Kaestner, Lars, Lipp, Peter
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Ca2+ signalling
Ca2+ sparks
Calcium - metabolism
Cells, Cultured
Chronic stimulation
Endothelin-1
Endothelin-1 - administration & dosage
Gq-coupled receptors
Infusion Pumps, Implantable
Male
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - metabolism
Phenylephrine
Protein kinase C
Rats
Rats, Wistar
Real time quantitative PCR
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Summary:Graphical abstract Chronic stimulation of rat adult cardiomyocytes with hormones signalling through Gq proteins induces cellular remodelling associated with increased arrhythmogenicity (ECT-extra calcium transients) (A), malfunctional calcium handling (B) and altered gene expression (DIV-days in vitro) (C).
ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2015.12.005