Use of haloperidol and risperidone in highly aggressive Swiss Webster mice by applying the model of spontaneous aggression (MSA)

•Animal model of spontaneous aggression is efficient to select aggressive individuals.•Haloperidol and risperidone were effective in reversal of aggressive behavior.•Risperidone and haloperidol increases immobility and reduce locomotor activity. Aggression is defined as the act in which an individua...

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Bibliographic Details
Published in:Behavioural brain research 2016-03, Vol.301, p.110-118
Main Authors: Fragoso, Viviane Muniz da Silva, Hoppe, Luanda Yanaan, Araújo-Jorge, Tânia Cremonini de, Azevedo, Marcos José de, Campos, Jerônimo Diego de Souza, Cortez, Célia Martins, Oliveira, Gabriel Melo de
Format: Article
Language:English
Subjects:
Aggression - drug effects
Animals
Exploratory Behavior - drug effects
Haloperidol
Haloperidol - pharmacology
Male
Mice
Model of spontaneous aggression
Models, Animal
Motor Activity - drug effects
Random Allocation
Risperidone
Risperidone - pharmacology
Tranquilizing Agents - pharmacology
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Summary:•Animal model of spontaneous aggression is efficient to select aggressive individuals.•Haloperidol and risperidone were effective in reversal of aggressive behavior.•Risperidone and haloperidol increases immobility and reduce locomotor activity. Aggression is defined as the act in which an individual intentionally harms or injures another of their own species. Antipsychotics are a form of treatment used in psychiatric routine. They have been used for decades in treatment of patients with aggressive behavior. Haloperidol and risperidone promote the control of psychiatric symptoms, through their respective mechanisms of action. Experimental models are obtained by behavioral, genetic, and pharmacological manipulations, and use a reduced number of animals. In this context, we applied the model of spontaneous aggression (MSA), originating the presence of highly aggressive mice (AgR) when reassembled in adulthood. We administered haloperidol and risperidone in escalating doses, for ten consecutive days. Using positive and negative control groups, we evaluated the effectiveness of these drugs and the reversal of the aggressive behavior, performing the tail suspension test (TST) and open field test (OFT) on 10th day of treatment and 10 days after its discontinuation. The results showed that both antipsychotic drugs were effective in AgR and reversed the aggressive phenotype, reducing the number of attacks by AgR and the extent of lesions in the subordinate mice (AgD) exposed to the pattern of aggressive behavior (PAB) of the aggressors. This conclusion is based on the reduction in the animals' motor and exploratory activity, and on the reversal of patterns of aggressive behavior. The association between the MSA and experiments with other therapeutic protocols and different antipsychotics can be an important methodology in the study of aggressive behavior in psychiatric patients.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2015.12.010