Significant association of the KIR2DL3/HLA-C1 genotype with susceptibility to Crohn’s disease

Abstract We aimed to analyze the possible association of KIR/HLA-C genotypes with the susceptibility to Crohn’s disease (CD) in a Spanish population. A total of 125 patients with CD and 339 healthy controls were selected for this study. KIR and HLA-C typing were developed by sequence-specific oligon...

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Bibliographic Details
Published in:Human immunology 2016-01, Vol.77 (1), p.104-109
Main Authors: Díaz-Peña, Roberto, Vidal-Castiñeira, Jose Ramón, Moro-García, Marco Antonio, Alonso-Arias, Rebeca, Castro-Santos, Patricia
Format: Article
Language:English
Subjects:
Allergy and Immunology
Crohn Disease - genetics
Crohn Disease - immunology
Crohn’s disease
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
HLA
HLA-C Antigens - genetics
Humans
Killer Cells, Natural - immunology
KIR
Linkage Disequilibrium
Natural killer
Polymorphism, Genetic
Receptors, KIR2DL2 - genetics
Receptors, KIR2DL3 - genetics
Spain
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Summary:Abstract We aimed to analyze the possible association of KIR/HLA-C genotypes with the susceptibility to Crohn’s disease (CD) in a Spanish population. A total of 125 patients with CD and 339 healthy controls were selected for this study. KIR and HLA-C typing were developed by sequence-specific oligonucleotide probing. We found that the centromeric A/A genotype and HLA-C1 combination was significantly increased in CD patients ( P < 10−3 ). The KIR2DL3/2DL3 genotype was significantly increased in CD patients ( P < 0.0005). Moreover, we also observed a highly significant increase of KIR2DL3-HLA-C1 homozygosis in CD patients ( P < 0.0005). Our results confirm the relevance of the KIR2DL2/KIR2DL3 genes and their interaction with HLA-C to CD. We show that the contribution of the KIR genes to CD susceptibility extends beyond the association with individual KIRs, with an imbalance between activating and inhibitory KIR genes seeming to influence the susceptibility to CD.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2015.10.020