m‑CPBA Mediated Metal Free, Rapid Oxidation of Aliphatic Amines to Oximes

An efficient, rapid oxidation of various aliphatic amines to oximes using m-CPBA as an oxidant in ethyl acetate is described. High conversion (100%) with >90% oxime selectivity is achieved at room temperature under catalyst-free conditions. Mild reaction conditions along with an easy work up proc...

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Bibliographic Details
Published in:Journal of organic chemistry 2016-02, Vol.81 (3), p.781-786
Main Authors: Patil, Vilas V, Gayakwad, Eknath M, Shankarling, Ganapati S
Format: Article
Language:English
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Summary:An efficient, rapid oxidation of various aliphatic amines to oximes using m-CPBA as an oxidant in ethyl acetate is described. High conversion (100%) with >90% oxime selectivity is achieved at room temperature under catalyst-free conditions. Mild reaction conditions along with an easy work up procedure offer lower byproduct formation and high selectivity for oximes in good yield and purity.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.5b01740