To Cut or Not to Cut: Discovery of a Novel Regulator of DNA Break Resection

Nucleolytic resection of DNA double-strand breaks is the crucial first step in their repair via homologous recombination. New findings by Tkáč et al. (2016) published in this issue of Molecular Cell identify HELB as a novel, cell-cycle-specific negative regulator of DNA end resection. Nucleolytic re...

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Bibliographic Details
Published in:Molecular cell 2016-02, Vol.61 (3), p.325-326
Main Authors: Daley, James M., Sung, Patrick
Format: Article
Language:English
Subjects:
Animals
DNA End-Joining Repair
DNA Helicases - metabolism
Female
Humans
Mammary Neoplasms, Experimental - enzymology
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Summary:Nucleolytic resection of DNA double-strand breaks is the crucial first step in their repair via homologous recombination. New findings by Tkáč et al. (2016) published in this issue of Molecular Cell identify HELB as a novel, cell-cycle-specific negative regulator of DNA end resection. Nucleolytic resection of DNA double-strand breaks is the crucial first step in their repair via homologous recombination. New findings by Tkáč et al. published in this issue of Molecular Cell identify HELB as a novel, cell-cycle-specific negative regulator of DNA end resection.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2016.01.022