Neonatal adiposity increases the risk of atopic dermatitis during the first year of life

Background Early nutrition and adiposity have been linked to atopic dermatitis (AD) development. Objective We sought to describe risk factors for AD in the first year of life in infants participating in the Cork BASELINE birth cohort study (n = 1537). Methods Prospective data on early-life events, i...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2016-01, Vol.137 (1), p.108-117
Main Authors: O'Donovan, Sinéad M., PhD, O'B. Hourihane, Jonathan, MD, Murray, Deirdre M., PhD, Kenny, Louise C., PhD, Khashan, Ali S., PhD, Chaoimh, Carol ní, PhD, Irvine, Alan D., MD, Kiely, Mairead, PhD
Format: Article
Language:English
Subjects:
Adiposity
Adult
Allergy and Immunology
Atopic dermatitis
Babies
Baby foods
Body Composition
Breastfeeding & lactation
Cohort Studies
Dermatitis, Atopic - epidemiology
eczema
Female
Health risk assessment
Humans
infant
infant feeding
Infant Nutritional Physiological Phenomena
Infant, Newborn
Male
Mothers
Nutrition
Risk Factors
vitamin D
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Summary:Background Early nutrition and adiposity have been linked to atopic dermatitis (AD) development. Objective We sought to describe risk factors for AD in the first year of life in infants participating in the Cork BASELINE birth cohort study (n = 1537). Methods Prospective data on early-life events, infant feeding, and nutritional and environmental exposures were collected at 15 weeks' gestation, birth, and 2, 6, and 12 months of age. Body composition was assessed by using air displacement plethysmography at day 2 and 2 months. The primary outcome, persistent AD, was determined if the UK Working Party Diagnostic Criteria were satisfied at both 6 and 12 months. Results At 6 and 12 months, the point prevalence of AD was 14.2% (99% CI, 10.5% to 17.8%) and 13.7% (99% CI, 10.3% to 17.6%), respectively; 7.5% (99% CI, 5.0% to 9.9%) of infants had AD at both 6 and 12 months of age. At hospital discharge, 35% of infants were exclusively breast-fed, decreasing to 14% by 2 months. Complementary feeding was commenced at a median of 19 weeks (interquartile range, 17-22 weeks; 19% at
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.05.035