HPV Infection of the Head and Neck Region and Its Stem Cells

The human papillomavirus (HPV) is an etiologic agent associated with the development of head and neck squamous carcinoma (HNSCC)—in particular, oropharyngeal squamous cell carcinoma. The HPV-positive HNSCC is characterized by genetic alterations, clinical progression, and therapeutic response, which...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Dental Research 2015-11, Vol.94 (11), p.1532-1543
Main Authors: Pullos, A.N., Castilho, R.M., Squarize, C.H.
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - virology
Cell cycle
Data analysis
Dentistry
Deoxyribonucleic acid
DNA
DNA damage
DNA Damage - physiology
Epigenetics
Genomes
Head & neck cancer
Head - virology
Head and Neck Neoplasms - etiology
Head and Neck Neoplasms - virology
Human papillomavirus
Humans
Immunization
Infections
Laboratories
Mutation
Neck
Neck - virology
Neoplastic Stem Cells - physiology
Neoplastic Stem Cells - virology
Nobel prizes
Oral cancer
Papillomavirus Infections - complications
Papillomavirus Infections - physiopathology
Papillomavirus Infections - prevention & control
Papillomavirus Vaccines - therapeutic use
Proteins
Squamous cell carcinoma
Stem cells
Stem Cells - physiology
Tobacco
Transplantation
Tumor cells
Tumors
Vaccination
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The human papillomavirus (HPV) is an etiologic agent associated with the development of head and neck squamous carcinoma (HNSCC)—in particular, oropharyngeal squamous cell carcinoma. The HPV-positive HNSCC is characterized by genetic alterations, clinical progression, and therapeutic response, which are distinct from HPV-negative head and neck cancers, suggesting that virus-associated tumors constitute a unique entity among head and neck cancers. Malignant stem cells, or cancer stem cells, are a subpopulation of tumor cells that self-renew, initiate new tumors upon transplantation, and are resistant to therapy, and their discovery has revealed novel effects of oncovirus infection in cancer. In this review, we provide a virus-centric view and novel insights into HPV-positive head and neck pathogenesis. We discuss the influence of cancer stem cells, HPV oncoproteins, altered molecular pathways, and mutations in cancer initiation and cancer progression. We compiled a catalogue of the mutations associated with HPV-positive HNSCC, which may be a useful resource for genomic-based studies aiming to develop personalized therapies. We also explain recent changes in mass vaccination campaigns against HPV and the potential long-term impact of vaccinations on the prevention and treatment of HPV-positive head and neck cancers.
ISSN:0022-0345
1544-0591
DOI:10.1177/0022034515605456