Dietary licorice root supplementation reduces diet‐induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland

SCOPE: We studied the impact of dietary supplementation with licorice root components on diet‐induced obesity, fat accumulation, and hepatic steatosis in ovariectomized C57BL/6 mice as a menopause model. MATERIALS AND METHODS: We evaluated the molecular and physiological effects of dietary licorice...

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Published in:Molecular nutrition & food research 2016-02, Vol.60 (2), p.369-380
Main Authors: Madak‐Erdogan, Zeynep, Gong, Ping, Zhao, Yiru Chen, Xu, Liwen, Wrobel, Kinga U, Hartman, James A, Wang, Michelle, Cam, Anthony, Iwaniec, Urszula T, Turner, Russell T, Twaddle, Nathan C, Doerge, Daniel R, Khan, Ikhlas A, Katzenellenbogen, John A, Katzenellenbogen, Benita S, Helferich, William G
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Animals
blood
Body Fat Distribution
Body Weight - drug effects
body weight changes
bone density
Botanical estrogens
Diet, High-Fat - adverse effects
Dietary Supplements
dual-energy X-ray absorptiometry
Estrogen receptor
fatty liver
Female
Flavanones - pharmacology
food consumption
gene expression
genes
Glycyrrhiza - chemistry
high fat diet
licorice
Licorice root
Lipid Metabolism - drug effects
liver
magnetic resonance imaging
mammary glands
Mammary Glands, Animal - drug effects
Menopause
Metabolism
mice
Mice, Inbred C57BL
Non-alcoholic Fatty Liver Disease - diet therapy
obesity
Ovariectomy
phenotype
Plant Roots - chemistry
subcutaneous fat
uterus
Uterus - drug effects
weight gain
Weight Gain - drug effects
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Summary:SCOPE: We studied the impact of dietary supplementation with licorice root components on diet‐induced obesity, fat accumulation, and hepatic steatosis in ovariectomized C57BL/6 mice as a menopause model. MATERIALS AND METHODS: We evaluated the molecular and physiological effects of dietary licorice root administered to ovariectomized C57BL/6 mice as root powder (LRP), extracts (LRE), or isolated isoliquiritigenin (ILQ) on reproductive (uterus and mammary gland) and nonreproductive tissues important in regulating metabolism (liver, perigonadal, perirenal, mesenteric, and subcutaneous fat). Quantitative outcome measures including body weight, fat distribution (magnetic resonance imaging), food consumption, bone density and weight (Dual‐energy X‐ray absorptiometry), and gene expression were assessed by the degree of restoration to the preovariectomized health state. We characterized histological (H&E and oil red O staining) and molecular properties (expression of certain disease markers) of these tissues, and correlated these with metabolic phenotype as well as blood levels of bioactives. CONCLUSION: Although LRE and ILQ provided some benefit, LRP was the most effective in reducing body weight gain, overall fat deposition, liver steatosis, and expression of hepatic lipid synthesis genes following ovariectomy. Our data demonstrate that licorice root provided improvement of multiple metabolic parameters under conditions of low estrogen and high‐fat diets without stimulating reproductive tissues.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.201500445