Osteocompatibility characterization of polyacrylonitrile carbon nanofibers containing bioactive glass nanoparticles

A kind of composite carbon nanofibers (CNF) containing bioactive glass (BG) nanoparticles was produced for bone regeneration by a combination of electrospinning and sol–gel techniques. To produce the BG, compounds such as calcium nitrate, triethyl phosphate and tetraethyl orthosilicate were used as...

Full description

Saved in:
Bibliographic Details
Published in:Carbon (New York) 2013-05, Vol.56, p.288-295
Main Authors: Yang, Q., Sui, G., Shi, Y.Z., Duan, S., Bao, J.Q., Cai, Q., Yang, X.P.
Format: Article
Language:English
Subjects:
Biomedical materials
Carbon fibers
Chemistry
Colloidal gels. Colloidal sols
Colloidal state and disperse state
Cross-disciplinary physics: materials science
rheology
Electrospinning
Exact sciences and technology
General and physical chemistry
Glass
In vitro testing
Materials science
Nanocrystalline materials
Nanofibers
Nanoparticles
Nanoscale materials and structures: fabrication and characterization
Physical and chemical studies. Granulometry. Electrokinetic phenomena
Physics
Precursors
Sol gel process
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A kind of composite carbon nanofibers (CNF) containing bioactive glass (BG) nanoparticles was produced for bone regeneration by a combination of electrospinning and sol–gel techniques. To produce the BG, compounds such as calcium nitrate, triethyl phosphate and tetraethyl orthosilicate were used as precursors and hydrolyzed to form a sol–gel solution, which was then added to a polyacrylonitrile (PAN) solution in N,N-dimethylformamide. The resulting mixture was electrospun to form PAN nanofibers containing the BG precursors. Upon oxidation and carbonization, the PAN nanofibers and BG precursors transformed into continuous CNF embedded with BG nanoparticles (CNF/BG). Through this fabrication technique, several CNF/BG composites were obtained by controlling the feeding ratios of the different precursors giving rise to BG nanoparticles with various compositions (i.e. containing 70–90mol% of SiO2 component). In vitro biomineralization in a simulated body fluid and co-culture with MC3T3-E1 osteoblasts studies were performed to evaluate the osteocompatibility of the CNF/BG nanoparticle composites. When compared to pure CNF, the CNF/BG composites showed an improved ability to promote the in vitro formation of apatite and MC3T3-E1 proliferation, which was found to be dependent upon the composition of BG nanoparticles.
ISSN:0008-6223
1873-3891
DOI:10.1016/j.carbon.2013.01.014