The effects of carbamazepine on macroinvertebrate species: Comparing bivalves and polychaetes biochemical responses

In the present study, the bivalve Scrobicularia plana and the polychaete Diopatra neapolitana were exposed to an increasing carbamazepine (CBZ) concentration gradient. Both species are among the most widely used bioindicators, and CBZ is one of the most commonly found drugs in the aquatic environmen...

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Bibliographic Details
Published in:Water research (Oxford) 2015-11, Vol.85, p.137-147
Main Authors: Freitas, Rosa, Almeida, Ângela, Pires, Adília, Velez, Cátia, Calisto, Vânia, Schneider, Rudolf J., Esteves, Valdemar I., Wrona, Frederick J., Figueira, Etelvina, Soares, Amadeu M.V. M.
Format: Article
Language:English
Subjects:
Alterations
Animals
Anticonvulsants - toxicity
Antioxidants - metabolism
Biochemistry
Biomarkers
Bivalvia
Bivalvia - drug effects
Bivalvia - metabolism
Carbamazepine - toxicity
Concentration gradient
Diopatra neapolitana
Exposure
Feeding
Lipid Peroxidation - drug effects
Lipids
Oxidative stress
Oxidative Stress - drug effects
Pharmaceutical drugs
Polychaeta - drug effects
Polychaeta - metabolism
Psychological effects
Scrobicularia plana
Stress concentration
Water Pollutants, Chemical - toxicity
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Summary:In the present study, the bivalve Scrobicularia plana and the polychaete Diopatra neapolitana were exposed to an increasing carbamazepine (CBZ) concentration gradient. Both species are among the most widely used bioindicators, and CBZ is one of the most commonly found drugs in the aquatic environment. After a chronic exposure (28 days), the results obtained revealed that CBZ induced biochemical alterations in both species. Our findings demonstrated that S. plana and D. neapolitana reduced the CBZ accumulation rate at higher CBZ concentrations, probably due to their capacity to decrease their feeding rates at stressful conditions. Nevertheless, this defence mechanism was not enough to prevent both species from oxidative stress. In fact, S. plana and D. neapolitana were not able to efficiently activate their antioxidant defence mechanisms which resulted in the increase of lipid peroxidation, especially at the highest CBZ concentrations. Comparing both species, it seems that S. plana was the most sensitive species since stronger biochemical alterations were observed in this species. •Chronic exposure to CBZ induced cell responses in D. neapolitana and S. plana.•Both species showed the ability to reduce the accumulation rate along the CBZ concentration gradient.•CBZ induced oxidative stress in D. neapolitana and S. plana.•Cellular damages were induced in both species which were not able to develop efficient defences.•S. plana is the most sensitive species.
ISSN:0043-1354
1879-2448
DOI:10.1016/j.watres.2015.08.003