N-Substitution dependent stereoselectivity switch in palladium catalyzed hydroalkynylation of ynamides: a regio and stereoselective synthesis of ynenamides

A highly general palladium catalysed regioselective hydroalkynylation of ynamides for versatile enamide building blocks with an alkyne tether is achieved with an N-substitution dependent stereoselectivity switch under very mild reaction conditions.

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (81), p.14996-14999
Main Authors: Dwivedi, Vikas, Babu, Madala Hari, Kant, Ruchir, Reddy, Maddi Sridhar
Format: Article
Language:English
Subjects:
Alkynes
Alkynes - chemical synthesis
Alkynes - chemistry
Amides - chemical synthesis
Amides - chemistry
Catalysis
Molecular Structure
Palladium
Palladium - chemistry
Stereoisomerism
Stereoselectivity
Switches
Synthesis
Tethers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A highly general palladium catalysed regioselective hydroalkynylation of ynamides for versatile enamide building blocks with an alkyne tether is achieved with an N-substitution dependent stereoselectivity switch under very mild reaction conditions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc06251a