TCC in Transplant Ureter—When and When Not to Preserve the Transplant Kidney

We present four cases of transitional cell carcinoma of the transplant ureter (TCCtu). In three cases, localized tumor resection and a variety of reconstructive techniques were possible. Transplant nephrectomy with cystectomy was performed as a secondary treatment in one locally excised case. Transp...

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Bibliographic Details
Published in:American journal of transplantation 2016-02, Vol.16 (2), p.704-711
Main Authors: Olsburgh, J., Zakri, R.H., Horsfield, C., Collins, R., Fairweather, J., O’Donnell, P., Koffman, G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
cancer/malignancy/neoplasia
Carcinoma, Transitional Cell - diagnosis
Carcinoma, Transitional Cell - etiology
clinical research/practice
clinical research/practice
kidney transplantation/nephrology
DNA fingerprinting
Female
Glomerular Filtration Rate
Graft Rejection
Graft Survival
Humans
kidney disease: malignant
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - surgery
Kidney Function Tests
Kidney Neoplasms - diagnosis
Kidney Neoplasms - etiology
Kidney Transplantation
kidney transplantation/nephrology
Kidney transplants
Laparoscopy
Literature reviews
Male
Middle Aged
Nephrectomy
Postoperative Complications
Prognosis
Risk Factors
Transitional cell carcinoma
Transplants
Transplants & implants
Ureter
Ureter - surgery
Ureter - transplantation
Young Adult
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Description
Summary:We present four cases of transitional cell carcinoma of the transplant ureter (TCCtu). In three cases, localized tumor resection and a variety of reconstructive techniques were possible. Transplant nephrectomy with cystectomy was performed as a secondary treatment in one locally excised case. Transplant nephroureterectomy was performed as primary treatment in one case. The role of oncogenic viruses and genetic fingerprinting to determine the origin of TCCtu are described. Our cases and a systematic literature review illustrate the surgical, nephrological, and oncological challenges of this uncommon but important condition.
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.13533