Rhabdomyolysis: risk factors and incidence in polytrauma patients in the absence of major disasters

Purpose Rhabdomyolysis is a syndrome caused by musculoskeletal tissue damage that leads to the release of large amounts of intracellular elements, which particularly affect renal function. The most common causes are severe trauma, ischemia, surgical procedures, and drug abuse. We aimed to determine...

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Bibliographic Details
Published in:European journal of trauma and emergency surgery (Munich : 2007) 2013-04, Vol.39 (2), p.131-137
Main Authors: Sousa, A., Paiva, J. A., Fonseca, S., Raposo, F., Valente, L., Vyas, D., Ribeiro, O., Pinto, R.
Format: Article
Language:English
Subjects:
Critical Care Medicine
Emergency Medicine
Injuries
Intensive
Kidneys
Medicine
Medicine & Public Health
Musculoskeletal system
Original Article
Risk factors
Sports Medicine
Surgery
Surgical Orthopedics
Trauma care
Traumatic Surgery
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Summary:Purpose Rhabdomyolysis is a syndrome caused by musculoskeletal tissue damage that leads to the release of large amounts of intracellular elements, which particularly affect renal function. The most common causes are severe trauma, ischemia, surgical procedures, and drug abuse. We aimed to determine the incidence of rhabdomyolysis by measuring muscle injury markers (CK, myoglobin), to identify pre/post-admission as well as iatrogenic risk factors for rhabdomyolysis in severe polytrauma, to clarify the relevance of orthopedic injuries and surgical treatment in the onset/worsening of rhabdomyolysis, and to correlate risk factors with its main complication—acute renal failure (ARF). Methods Prospective study of severe polytrauma patients (Injury Severity Score (ISS) >15), with CK and myoglobin values measured at admission and after 24, 48, and 72 h. Peak values, variations between admission and peak, and variations between admission and day 3 were all determined. The correlations of those values with the onset of ARF and other negative outcomes were assessed. Results A total of 57 consecutive patients with a median ISS of 29 were included. ARF was present in 20 patients (38 %). CK-0 level was correlated with male gender ( p  
ISSN:1863-9933
1863-9941
DOI:10.1007/s00068-012-0233-7