Ductal metaplasia in oesophageal submucosal glands is associated with inflammation and oesophageal adenocarcinoma

Aims Recent studies have suggested that oesophageal submucosal gland (ESMG) ducts harbour progenitor cells that may contribute to oesophageal metaplasia. Our objective was to determine whether histological differences exist between the ESMGs of individuals with and without oesophageal adenocarcinoma...

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Bibliographic Details
Published in:Histopathology 2015-12, Vol.67 (6), p.771-782
Main Authors: Garman, Katherine S, Kruger, Leandi, Thomas, Samantha, Swiderska-Syn, Marzena, Moser, Barry K, Diehl, Anna Mae, McCall, Shannon J
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adult
Aged
Aged, 80 and over
Barrett's oesophagus
ductal metaplasia
Esophageal Neoplasms - pathology
Esophageal Neoplasms - surgery
Esophagectomy
Esophagus - pathology
Esophagus - surgery
Female
Humans
Inflammation - pathology
Inflammation - surgery
Male
Metaplasia - pathology
Metaplasia - surgery
Middle Aged
oesophageal neoplasm
oesophageal submucosal gland
oesophagus
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Summary:Aims Recent studies have suggested that oesophageal submucosal gland (ESMG) ducts harbour progenitor cells that may contribute to oesophageal metaplasia. Our objective was to determine whether histological differences exist between the ESMGs of individuals with and without oesophageal adenocarcinoma (EAC). Methods and results We performed histological assessment of 343 unique ESMGs from 30 control patients, 24 patients with treatment‐naïve high‐grade columnar dysplasia (HGD) or EAC, and 23 non‐EAC oesophagectomy cases. A gastrointestinal pathologist assessed haematoxylin and eosin‐stained ESMG images by using a scoring system that assigns individual ESMG acini to five histological types (mucous, serous, oncocytic, dilated, or ductal metaplastic). In our model, ductal metaplastic acini were more common in patients with HGD/EAC (12.7%) than in controls (3.5%) (P = 0.006). We also identified greater proportions of acini with dilation (21.9%, P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.12707