Management and Outcomes of Patients with Occlusive Thrombosis after Pediatric Cardiac Surgery

Objectives To evaluate management and outcomes of thrombosis after pediatric cardiac surgery and stratify thrombi according to risk of short- and long-term complications to better guide therapeutic choices. Study design Retrospective review was performed of 513 thrombi (400 occlusive) diagnosed afte...

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Bibliographic Details
Published in:The Journal of pediatrics 2016-02, Vol.169, p.146-153
Main Authors: Manlhiot, Cedric, PhD, Brandão, Leonardo R., MD, Schwartz, Steven M., MD, Sivarajan, V. Ben, MD, Williams, Suzan, MD, Collins, Tanveer H., MD, McCrindle, Brian W., MD, MPH
Format: Article
Language:English
Subjects:
Cardiac Surgical Procedures
Child
Child, Preschool
Humans
Infant
Infant, Newborn
Pediatrics
Postoperative Complications - therapy
Retrospective Studies
Risk Assessment
Thrombosis - classification
Thrombosis - therapy
Treatment Outcome
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Summary:Objectives To evaluate management and outcomes of thrombosis after pediatric cardiac surgery and stratify thrombi according to risk of short- and long-term complications to better guide therapeutic choices. Study design Retrospective review was performed of 513 thrombi (400 occlusive) diagnosed after 213 pediatric cardiac operations. Long-term outcomes over time were assessed with the use of parametric hazard regression models. Results Serious complications and/or high-intensity treatment occurred with 17%-24% of thrombi depending on location, most commonly in thrombi affecting the cardiac and cerebral circulation. Bleeding complications affected 13% of patients; associated factors included thrombolytics (OR 8.7, P  
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2015.10.046