Association of metabolic complications with plasma mid-regional pro-adrenomedullin level in stable kidney transplant recipients

Recently, increased plasma mid-regional pro-adrenomedullin (MR-proADM) concentrations have been demonstrated in patients with chronic renal failure. In this study, we attempted to identify significant clinical factors associated with MR-proADM concentration in stable kidney transplant recipients. Fo...

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Bibliographic Details
Published in:Clinica chimica acta 2016-01, Vol.453, p.160-163
Main Authors: Suzuki, Yosuke, Katagiri, Fumihiko, Sato, Fuminori, Fujioka, Takashi, Tanaka, Ryota, Sato, Yuhki, Mimata, Hiromitsu, Itoh, Hiroki
Format: Article
Language:English
Subjects:
Adolescent
Adrenomedullin - blood
Adult
Aged
Female
Humans
Hyperlipidemia
Hypertension
Kidney transplantation
Kidney Transplantation - adverse effects
Male
Metabolic complications
Mid-regional pro-adrenomedullin
Middle Aged
Postoperative Complications - blood
Postoperative Complications - etiology
Postoperative Complications - metabolism
Protein Precursors - blood
Young Adult
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Summary:Recently, increased plasma mid-regional pro-adrenomedullin (MR-proADM) concentrations have been demonstrated in patients with chronic renal failure. In this study, we attempted to identify significant clinical factors associated with MR-proADM concentration in stable kidney transplant recipients. Forty-seven Japanese kidney transplant recipients who underwent transplantation >180days prior to the study were analyzed. To facilitate comparability of anti-hypertensive regimens across recipients taking different drugs, we calculated the treatment intensity score of anti-hypertensive drugs in each recipient. Morning blood samples were collected and plasma MR-proADM concentrations were measured using an enzyme immunoassay. Multiple regression analysis identified treatment intensity score for anti-hypertensive drugs, serum albumin, creatinine clearance and use of lipid-lowering agents as significant independent factors associated with plasma MR-proADM concentration. Adjusted coefficient of determination for this model was 0.46. Apart from indicating lowered renal function, plasma MR-proADM concentration may be a useful biomarker for metabolic disorders, especially hypertension and hyperlipidemia, in stable kidney transplant patients. •Kidney transplant recipients at least 180days after transplantation were studied.•Anti-hypertensive treatment intensity and use of lipid-lowering agents are associated with MR-proADM.•MR-proADM may be a useful biomarker for metabolic disorders in stable kidney transplant recipients.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2015.12.016