Antibacterial drug discovery in the resistance era

The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians, researchers, policymakers, politicians and the public at large. The evolution and widespread distribution of antibiotic-resistance elements in bacterial pathogens has made diseases that were once easily treatabl...

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Bibliographic Details
Published in:Nature (London) 2016-01, Vol.529 (7586), p.336-343
Main Authors: Brown, Eric D., Wright, Gerard D.
Format: Article
Language:English
Subjects:
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631/326
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Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobial agents
Bacteria
Bacteria - cytology
Bacteria - drug effects
Bacteria - genetics
Bacteria - metabolism
Bacterial infections
Cell growth
Drug Discovery - methods
Drug Discovery - trends
Drug resistance
Drug Resistance, Bacterial - drug effects
Enzymes
Genes, Bacterial - drug effects
Genes, Essential - drug effects
Humanities and Social Sciences
Humans
Metabolites
Microorganisms
multidisciplinary
Mutation
Pathogens
Pharmaceutical research
Prevention
review-article
Science
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Summary:The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians, researchers, policymakers, politicians and the public at large. The evolution and widespread distribution of antibiotic-resistance elements in bacterial pathogens has made diseases that were once easily treatable deadly again. Unfortunately, accompanying the rise in global resistance is a failure in antibacterial drug discovery. Lessons from the history of antibiotic discovery and fresh understanding of antibiotic action and the cell biology of microorganisms have the potential to deliver twenty-first century medicines that are able to control infection in the resistance era.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature17042