Single-stage endoscopic treatment for mild to moderate acute cholangitis associated with choledocholithiasis: a multicenter, non-randomized, open-label and exploratory clinical trial

Background Two‐stage treatment involving stone removal after drainage is recommended for mild to moderate acute cholangitis associated with choledocholithiasis. However, single‐stage treatment has some advantages. We aimed to assess the efficacy and safety of single‐stage endoscopic treatment for mi...

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Bibliographic Details
Published in:Journal of hepato-biliary-pancreatic sciences 2015-12, Vol.22 (12), p.825-830
Main Authors: Eto, Kazunori, Kawakami, Hiroshi, Haba, Shin, Yamato, Hiroaki, Okuda, Toshinori, Yane, Kei, Hayashi, Tsuyoshi, Ehira, Nobuyuki, Onodera, Manabu, Matsumoto, Ryusuke, Matsubara, Yu, Takagi, Tomofumi, Sakamoto, Naoya
Format: Article
Language:English
Subjects:
Acute cholangitis
Adult
Aged
Aged, 80 and over
Bile
Bile duct stone
Biliary drainage
Body temperature
Cholangiopancreatography, Endoscopic Retrograde - methods
Cholangitis - complications
Cholangitis - surgery
Choledocholithiasis - complications
Choledocholithiasis - surgery
Clinical trials
Endoscopic sphincterotomy
Endoscopy
Female
Humans
Male
Middle Aged
Single-stage treatment
Sphincterotomy, Endoscopic - methods
Treatment Outcome
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Summary:Background Two‐stage treatment involving stone removal after drainage is recommended for mild to moderate acute cholangitis associated with choledocholithiasis. However, single‐stage treatment has some advantages. We aimed to assess the efficacy and safety of single‐stage endoscopic treatment for mild to moderate acute cholangitis associated with choledocholithiasis. Methods A multicenter, non‐randomized, open‐label, exploratory clinical trial was performed in 12 institutions. A total of 50 patients with a naïve papilla and a body temperature ≥37 °C who were diagnosed with mild to moderate cholangitis associated with choledocholithiasis were enrolled between August 2012 and February 2014. Results Of the 50 patients, 15 had mild cholangitis and 35 had moderate cholangitis. The median number of common bile duct stones was 2 (range, 1–8), and the median diameter of the common bile duct stones was 7.5 mm (range, 1–18). The cure rate of acute cholangitis within 4 days after single‐stage treatment was 90% (45/50) based on a body temperature
ISSN:1868-6974
1868-6982
DOI:10.1002/jhbp.296