Effects of Paroxetine,a CYP2D6 Inhibitor, on the Pharmacokinetic Properties of Hydrocodone After Coadministration With a Single-entity,Once-daily, Extended-release HydrocodoneTablet

Additionally, we agree with the 2013 finding of Drs. Navani and Yoburn, "following subcutaneous administration, norhydrocodone was ~70-fold less potent than hydrocodone in producing analgesia." Because the circulating norhydrocodone is one third of the parent hydrocodone1 and is also ~70-f...

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Bibliographic Details
Published in:Clinical therapeutics 2016, Vol.38 (1), p.228-229
Main Authors: Kapil, Ram P., PhD, Friedman, Kristen, MPH, Cipriano, Alessandra, MSHS, Michels, Gregory, MS, Shet, Manjunath, PhD, Mondal, Sabiha, MD, Harris, Stephen C., MD
Format: Article
Language:English
Subjects:
Analgesics
Conflicts of interest
Internal Medicine
Medical Education
Prescription drugs
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Summary:Additionally, we agree with the 2013 finding of Drs. Navani and Yoburn, "following subcutaneous administration, norhydrocodone was ~70-fold less potent than hydrocodone in producing analgesia." Because the circulating norhydrocodone is one third of the parent hydrocodone1 and is also ~70-fold less potent than the parent hydrocodone, we consider the contribution of analgesic activity of norhydrocodone from oral hydrocodone to be relatively minimal.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2015.10.024