Aggressive responding in abstinent heroin addicts: neuroendocrine and personality correlates

Objective measures of experimentally induced aggressiveness were evaluated in 20 abstinent heroin-dependent subjects, in comparison with 20 normal healthy male subjects. All the subjects were preliminarily submitted to DSM-IV interviews, Buss–Durkee Hostility Inventory (BDHI) and Minnesota Multiphas...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2004, Vol.28 (1), p.129-139
Main Authors: Gerra, Gilberto, Zaimovic, Amir, Moi, Gabriele, Bussandri, Monica, Bubici, Cristina, Mossini, Matteo, Raggi, Maria Augusta, Brambilla, Francesca
Format: Article
Language:English
Subjects:
ACTH
Adrenocorticotropic Hormone - blood
Adult
Aggression - drug effects
Aggression - psychology
Aggressiveness
Area Under Curve
Cortisol
Dependence
Epinephrine
Epinephrine - blood
Hemodynamics - physiology
Heroin
Heroin Dependence - physiopathology
Heroin Dependence - psychology
Hormones - blood
Humans
Hydrocortisone - blood
Male
MMPI
Neuropsychological Tests
Neurosecretory Systems - drug effects
Neurosecretory Systems - physiology
Norepinephrine
Norepinephrine - blood
Personality - physiology
Psychiatric Status Rating Scales
Substance Withdrawal Syndrome - physiopathology
Substance Withdrawal Syndrome - psychology
Temperament
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Summary:Objective measures of experimentally induced aggressiveness were evaluated in 20 abstinent heroin-dependent subjects, in comparison with 20 normal healthy male subjects. All the subjects were preliminarily submitted to DSM-IV interviews, Buss–Durkee Hostility Inventory (BDHI) and Minnesota Multiphasic Personality Inventory (MMPI II). During a laboratory task, the Point Subtraction Aggression Paradigm (PSAP), subjects earned monetary reinforcers with repeated button presses and were provoked by the subtraction of money, which was attributed to a fictitious other participant. Subjects could respond by ostensibly subtracting money from the fictitious subject (the aggressive response). Money-earning responses were not different in drug-free heroin addicts and controls during the first two sessions and significantly lower during the third session in heroin-dependent subjects ( t=2.99, P
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2003.09.029