Tumor necrosis factor genomic polymorphism in Spanish IGA deficiency patients

Selective IgA deficiency (IgAD) is the most common form of primary immunodeficiency. Its association with genes within the major histocompatibility complex (MHC) has been repeatedly reported. Recently the susceptibility gene has been located in the class III region, around the tumor necrosis factor...

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Bibliographic Details
Published in:Tissue antigens 2000-04, Vol.55 (4), p.359-363
Main Authors: De la Concha, E.G., Fernandez-Arquero, M., Vigil, P., Lazaro, F., Ferreira, A., Garcia-Rodriguez, M.C., Fontan, G.
Format: Article
Language:English
Subjects:
Alleles
gene association
Gene Frequency
Haplotypes
HLA
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Humans
IgA deficiency
IgA Deficiency - genetics
IgA Deficiency - immunology
Microsatellite Repeats
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
Promoter Regions, Genetic - immunology
Spain
TNF
Tumor Necrosis Factor-alpha - genetics
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Summary:Selective IgA deficiency (IgAD) is the most common form of primary immunodeficiency. Its association with genes within the major histocompatibility complex (MHC) has been repeatedly reported. Recently the susceptibility gene has been located in the class III region, around the tumor necrosis factor (TNF) cluster. In this study we have examined IgAD association with TNF‐α gene promoter polymorphisms and TNFa and b microsatellites. No significant association was found with the former polymorphisms and the observed associations with TNFa2 allele and haplotypes TNFa2b1 and TNFa2b3 were proven to be secondary to their occurrence on the B14‐DR1 and B8‐DR3 haplotypes, previously reported to be associated with susceptibility to IgAD. However, a primary negative (protective) association was found between the TNFa10 allele and IgAD.
ISSN:0001-2815
1399-0039
DOI:10.1034/j.1399-0039.2000.550410.x