Absence of hSNF5/INI1 mutation in human lung cancer

Frequent occurrence of chromosome 22q deletions in lung cancer indicates the presence of a tumor suppressor gene on this chromosome arm. The hSNF5/INI1 gene at chromosome 22q11.2 has recently been shown to act as a tumor suppressor in rhabdoid tumors. To investigate whether the hSNF5/INI1 gene locat...

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Bibliographic Details
Published in:Cancer letters 2000-05, Vol.153 (1), p.57-61
Main Authors: Manda, Ryokuhei, Kohno, Takashi, Hamada, Kunihiro, Takenoshita, Seiichi, Kuwano, Hiroyuki, Yokota, Jun
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosomal Proteins, Non-Histone
chromosome 22
DNA Mutational Analysis
DNA-Binding Proteins - genetics
Exons - genetics
Gene Frequency
hSNF5/INI1 gene
Humans
INI1 gene
Introns - genetics
Lung cancer
lung carcinoma
Lung Neoplasms - genetics
Medical sciences
Mutation
Pneumology
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Polymorphisms
SMARCB1 Protein
SNF5 gene
Transcription Factors
Tumor Cells, Cultured
Tumors of the respiratory system and mediastinum
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Summary:Frequent occurrence of chromosome 22q deletions in lung cancer indicates the presence of a tumor suppressor gene on this chromosome arm. The hSNF5/INI1 gene at chromosome 22q11.2 has recently been shown to act as a tumor suppressor in rhabdoid tumors. To investigate whether the hSNF5/INI1 gene located on chromosome 22q is involved in lung carcinogenesis, mutation analysis of the hSNF5/INI1 gene was performed using 50 lung cancer cell lines. No mutations causing amino acid substitutions or frameshifts were found by PCR-SSCP analysis of the entire coding region. The results indicated that the hSNF5/INI1 gene is not inactivated in lung cancers and suggested the presence of another tumor suppressor gene on chromosome 22q. Thus, further studies are necessary to identify the target lung tumor suppressor gene(s) on chromosome 22q.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(00)00342-6