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Visualizing Fluoride Ion in Mitochondria and Lysosome of Living Cells and in Living Mice with Positively Charged Ratiometric Probes

Two ratiometric probes fluoride ion, Mito-F and Lyso-F, were rationally designed and synthesized with positive charges at physiological conditions. The positive charges functioned as target moieties for subcellular mitochondria and lysosome of living cells, and effective sequesters of fluoride ion f...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2015-09, Vol.87 (17), p.8613-8617
Main Authors: Wu, Zhisheng, Tang, Xinjing
Format: Article
Language:English
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Summary:Two ratiometric probes fluoride ion, Mito-F and Lyso-F, were rationally designed and synthesized with positive charges at physiological conditions. The positive charges functioned as target moieties for subcellular mitochondria and lysosome of living cells, and effective sequesters of fluoride ion for fast and efficient fluorescent detection. In addition, in vivo imaging of fluoride ion in living mice was successfully achieved for the first time using probe Mito-F.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.5b02578