Minimal stimulation IVF vs conventional IVF: a randomized controlled trial

Background Minimal stimulation in vitro fertilization (mini–in vitro fertilization) is an alternative in vitro fertilization treatment protocol that may reduce ovarian hyperstimulation syndrome, multiple pregnancy rates, and cost while retaining high live birth rates. Objective We performed a random...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2016, Vol.214 (1), p.96.e1-96.e8
Main Authors: Zhang, John J., MD, PhD, Merhi, Zaher, MD, Yang, Mingxue, MD, PhD, Bodri, Daniel, MD, PhD, Chavez-Badiola, Alejandro, MD, Repping, Sjoerd, PhD, van Wely, Madelon, PhD
Format: Article
Language:English
Subjects:
Adult
clomiphene citrate
Female
Fertilization in Vitro - adverse effects
Fertilization in Vitro - methods
Gonadotropins - therapeutic use
Humans
Infertility, Female - therapy
Infertility, Male - therapy
IVF
Live Birth
Male
mini-IVF
multiple pregnancy
Obstetrics and Gynecology
OHSS
Ovarian Hyperstimulation Syndrome - etiology
Pregnancy
Pregnancy Rate
Pregnancy, Multiple
Single Embryo Transfer
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Summary:Background Minimal stimulation in vitro fertilization (mini–in vitro fertilization) is an alternative in vitro fertilization treatment protocol that may reduce ovarian hyperstimulation syndrome, multiple pregnancy rates, and cost while retaining high live birth rates. Objective We performed a randomized noninferiority controlled trial with a prespecified border of 10% that compared 1 cycle of mini–in vitro fertilization with single embryo transfer with 1 cycle of conventional in vitro fertilization with double embryo transfer. Study Design Five hundred sixty-four infertile women (
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2015.08.009